2 funded postdoc positions: ERC project

il y a 2 semaines


Bruxelles, Région de Bruxelles, Belgique TN Belgium Temps plein

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2 funded postdoc positions: ERC project - de novo protein design, high-throughput biophysics

Client: VIB

Location: Brussels

Job Category: Other

EU work permit required: Yes

Job Reference: c1921dd74137

Job Views: 3

Posted: 06.03.2025

Expiry Date: 20.04.2025

Job Description:

Overview

Two postdoc positions are available at the Laboratory of Computational Protein Design in Brussels and are funded by an ERC grant. The focus of the group is the de novo design of membrane proteins and nanopores for applications such as single-molecule sensing. In that context, this ERC project aims to (i) develop a new experimental platform for high-throughput characterization of the biophysical properties of natural and synthetic protein nanopores and (ii) leverage the generated data for the development of better computational design methods based on the Rosetta software and the latest generative deep learning software for protein design.

We are therefore looking for two profiles with interest in the design of membrane proteins:

Profile 1

Demonstrated experience in:

  • Developing and using high-throughput assays.
  • Library construction (mutagenesis, oligo pools).
  • Recombinant expression, purification and characterization of proteins.
  • Deep sequencing and analysis.

Experience with membrane proteins and/or cell-free expression will be regarded as a plus.

Profile 2

Demonstrated experience in:

  • Modelling/design of protein with Rosetta, AlphaFold and/or deep learning.
  • Deep sequencing data analysis and interpretation.
  • Good understanding of (membrane) protein structure.

The two candidates will collaborate and should therefore have excellent verbal and written English communication to facilitate inter-disciplinary work.

We offer

  • State-of-the-art structural biology, computing, and protein engineering facilities.
  • Excellent training in academic, technical, and career skills.
  • A stimulating and supportive international research environment.
  • VIB provides competitive salary and benefits, as well as participation in national social security, healthcare, and retirement plans.
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