PhD position: Understanding defective calcium handling contributing to cardiac arrhythmias
il y a 1 semaine
We are looking for an enthusiastic and highly motivated candidate with a Master degree in Biomedical or Life Sciences (or equivalent). In depth knowledge of relevant areas, in particular cardiovascular system and cell physiology is expected.You are flexible, able to work independently as well as in a team and have a problem-solving attitude.You are interested to work with samples from patients and large animal models.You are motivated to work in a multidisciplinary research team and have good communication skills in English.You are expected to write a doctoral thesis within 4 years.A creative and technical mindset is a plus.The team of Prof. Eef Dries is recruiting a PhD student to study underlying mechanisms contributing to arrhythmogenesis in cardiac disease. We previously studied aberrant Ca2+ handling (ectopic calcium release events) in isolated single cardiomyocytes in the onset of arrhythmia after disease remodelling (Dries et al The obtained findings were translated to in vivo using a large animal model with myocardial infarction (Dries & Amoni et al As a continuation of this work and to gain deeper insights into how changes in cardiomyocyte physiology affect tissue function, we will use a new living tissue slice experimental model in which calcium and voltage changes can be simultaneously monitored. Using this slice model in which cell-cell and cell-matrix interactions are preserved, a more physiological perspective of the impact of cardiomyocyte dysfunction and greater insights into the impact on the intact organ can be obtained.The research project is centred around the following objectives:Understanding how aberrant calcium handling contributes to arrhythmogenesis in diseased cardiac tissue.Testing interventions that could modify defective calcium handling in cardiac tissue.The candidate will prepare living cardiac slices from human samples of different disease etiologies and perform advanced live calcium and voltage imaging, which they will combine with molecular analysis (Dries et al Identified mechanisms will then be targeted using pharmacological interventions and/or genetic modifications.Key methodologies used in this project include: living cardiac tissue slices (Watson et al. 2017), live fluorescent imaging (calcium and voltage indicators), cardiac tissue culture, confocal microscopy, immunostaining, immunoblotting, viral vectors and transduction.The team has a long-standing expertise in cardiac electrophysiology, Ca2+ homeostasis and remodelling with disease. Extensive facilities are available for functional imaging, electrophysiology, access to large animal models and human cardiac tissue samples. The research group has several postdocs and doctoral students.Funding is available to support the position and the research.The candidate will enroll in the Doctoral School offering further training and complementary skills' development.Selected References:Dries E, et al. Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons. Cardiovasc Res : doi:10.1093/cvr/cvy088.Dries E, Amoni M, et al. Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability. J Physiol. 2020 Jul;598(14): doi: /JP278839.Dries E, et al. CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices. J Gen Physiol. 2021 Jun 7;153(6):e doi: /jgp Watson S, et al. Preparation of viable adult ventricular myocardial slices from large and small mammals. Nat Protoc : doi: /nprot The Lab of Experimental Cardiology is part of the Department of Cardiovascular Sciences at the KU Leuven and includes research teams led by Prof. Eef Dries and Prof. Llewelyn Roderick. The joint focus of our teams is to study cellular and molecular mechanisms that underlie the physiological and structural changes in the heart that occur during disease and ageing that contribute to decreased function and arrhythmia. Our experimental approach combines a variety of advanced physiological and molecular technologies, ranging from single cell analysis to the use of multicellular native and engineered preparations as well as in vivo. The goal is to bridge the gap between basic research and clinical observations with the ultimate aim of defining new targets for therapy.We offer a fully funded doctoral fellowship (based on successful intermediate evaluation after 1 year).We provide excellent research facilities and opportunities for broader skill development (training, education and career development).You will be part of a multinational research group.
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PhD position
il y a 1 semaine
Leuven, Flandre, Belgique KU Leuven Temps pleinYou possess a master degree in psychology, educational sciences, business, social sciences, or related fields, with outstanding academic achievements;You demonstrate a strong interest in labor market subjects, engaging in research related to significant policy and societal issues;You are proficient in English;You find pleasure in the writing process and are...
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Phd Position
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Leuven, Flandre, Belgique Springer Nature Temps pleinPhD position - Impact of gender-affirming therapy on bone:EmployerKU LeuvenLocationLeuvenSalarynvtClosing date14 May 2024Discipline Engineering, Health Science Job Type PhD Position Employment - Hours Full time Duration Fixed term Qualification Masters Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob...
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PhD position
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PhD Position in Planetary Sciences at
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PhD: AI for data-driven representation optimization for time series
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ERC-funded PhD Position in Molecular Genetics
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Marie Curie Phd Position On sound Quality of
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Leuven, Flandre, Belgique KU Leuven Temps pleinAre you a Medicine master's graduate with a keen interest in immunology?Recognize the benefits of pursuing a PhD for future specialization and career prospects in healthcare and industry.Show genuine enthusiasm for scientific research.Enjoy collaborating with a multidisciplinary team of healthcare professionals and researchers.Demonstrate creativity,...
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Marie Curie Phd Position On sound Quality of
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Phd Position in Gut Microbial Ecology
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Leuven, Flandre, Belgique Springer Nature Temps pleinPhD position in gut microbial ecology:EmployerVIBLocationLeuvenClosing date18 Mar 2024Discipline Life Science Job Type PhD Position Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob Details: Profile MSc degree in microbiology,...
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PhD Position on Modeling of Energy Systems and Markets
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Leuven, Flandre, Belgique EnergyVille Temps pleinBeschrijving At the division of Applied Mechanics and Energy Conversion (TME) of the Department of Mechanical Engineering at KU Leuven, and embedded in EnergyVille, a dynamic research group led by prof. Erik Delarue is working on the modeling of energy systems and markets (unit commitment, system planning, equilibrium modeling, renewables integration,...
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PhD position: Machine Learning
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Leuven, Flandre, Belgique Siemens Industry Software NV Temps pleinWe're Hiring, World Let'smake the difference together Video: SiemensDigital Industries (DI) is an innovation leader in automation anddigitalization. Closely, collaborating with partners and customers, we careabout the digital transformation in the process and discrete industries. Withour Digital Enterprise portfolio, we provide and encourage companies...
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Phd Position in Gut Microbial Ecology
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PhD Position in Medicinal Chemistry
il y a 1 semaine
Leuven, Flandre, Belgique KU Leuven Temps pleinWe are seeking a highly motivated candidate with a collaborative mindset to join our team.Candidates should conduct research with integrity, precision, and meet deadlinesApplicants must have a Master's degree in Chemistry, Pharmaceutical Sciences, Chemical/Biological Engineering or a related fieldPrior extensive background in synthetic organic chemistry is...
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Leuven, Flandre, Belgique UNIVERSITAT FRANKFURT Temps pleinJob Title: PhD Student Position on Gravitational Lensing Data Analysis Company: University of Louvain (UCLouvain), Belgium Join the gravitational-wave (GW) group at UCLouvain's Centre for Cosmology, Particle Physics, and Phenomenology for a fascinating four-year PhD student position focusing on gravitational lensing data analysis for ground-based GW...
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Global PhD Partnerships
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Leuven, Flandre, Belgique KU Leuven Temps pleinReceive job alerts that match your preferences.Global PhD Partnerships KU Leuven-University of Melbourne: A joint experimental/numerical study of hydrogen combustion in reciprocating enginesKU Leuven is an autonomous university. It was founded in 1425. It was born of and has grown within the Catholic tradition.At the University of Melbourne, the Combustion...
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Leuven, Flandre, Belgique KU Leuven Temps pleinYou have a master's degree in engineering with a background in any of the following domains: electrical or mathematical engineering, biomedical engineering, computer science, information technology, artificial intelligence, signal processing (or a similar degree with an equivalent academic level). You like mathematics and you have a solid...
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Phd Position in The Field of Rare Amyloidosis
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PhD position on cellular self-organization during development
il y a 1 semaine
Leuven, Flandre, Belgique KU Leuven Temps pleinTalented and enthusiastic molecular and cellular biology researcher. Master degree in bioengineering, biology, biotechnology, or similar. Good grasp of molecular and developmental biology as well as genetics with an interest in interdisciplinary work. Study results should show high aptitude and research interest Good communicative skills and a...
