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Site Name:
Belgium-Rixensart

Posted Date:
Mar

//Field based worker, expected to be on-site//

We are looking for a motivated expert scientist for in-process analytics of mRNA-based vaccines to join the mRNA drug substance Development Unit and be part of the integration of an external partner Drug Substance platform process for clinical & commercial manufacturing of mRNA.

Located in Rixensart, Belgium, the position will play a significant role in shaping current and next generation GSK's leading mRNA vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health.

This role provides the opportunity to integrate a diverse group of top talented experts in vaccines' industry, lead key activities and further grow and progress in your career.

As a Drug Substance organization our main goal is to deliver high quality mRNA starting from the initial template to the final bulk product.

As this process can be complex and tedious, getting an in-depth understanding of the relationships that exist between the process and the product is crucial to streamline our development activities in a competitive environment.

This in-depth understanding requires the development or the set-up of various analytical assays (process or product related impurities, product characterization) to monitor the evolution of the product quality throughout the process

As an expert scientist you will join a team of experts in the mRNA field and contribute to building up our process understanding and consolidate our assets in the field.

Your responsibilities:

- and product-related impurities) to support development of new mRNA Drug Substance processes for clinical & commercial manufacturing of mRNA.

• Development of fit for purpose assays to further strengthen our process understanding in collaboration with the Inprocess analytics or analytical development teams
• Liaise and coordinate with transversal teams (Analytical development, In-Process analytics, External partners) and contribute to building our next generation mRNA platform workflows and integration within the laterstage global platform.
• Stay up to date with best practices and advancements in the mRNA technology on analytical methodologies and latest quality and regulatory guidance to support project documentation and accelerated CMC submissions.
• Train and supervise your colleagues on the different assays developed

_ Why you?_

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in bio-engineering, biochemistry, biotechnology, chemistry or equivalent or a Master in bio-engineering, biochemistry, biotechnology, chemistry or equivalent.
• A minimum of 35 years' (if PhD) or 58years' (if Master) of handson experience in the development of nucleic acids characterization methods (fluorescentbased assays, RTqPCR, ddPCR, hybridization technique, electrophoresisbased techniques, HPLC/UPLC).
• Excel at complex problem solving through critical thinking using knowledge gained through formal education, experience, and sound judgment.
• Excellent communication skills and demonstrated experience in managing stakeholders in tight timelines

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience with Quality by Design with demonstrated capability to develop fit-for-purpose high throughput in process analytics to support process development for biologics.
• Knowledge on mRNA structure and function relation.
• Firsthand experience with advanced NGS.
• Broad understanding of analytical development workflows required for CMC support.

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive.

Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people.

While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive.

We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy.

We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

**Important notice to Employment businesses/ Agencies

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