Postdoctoral researcher to study the role of Tau, MEG3, and necroptosis in Alzheimer's Disease

il y a 1 semaine


Leuven, Flandre, Belgique VIB Temps plein

Description

The team led by Prof. Bart De Strooper focuses on addressing key issues related to Alzheimer's disease. We are currently seeking a dedicated postdoctoral scientist to join our project on neuroinflammation and microglia-neuron interactions, building on our recent discoveries regarding the impact of programmed cell death on Alzheimer's Disease and its connection to Tau pathology. In this project, we will explore how the non-coding RNA MEG3 triggers necroptosis and the formation of granulo-vacuolar bodies in neurons. The selected candidate will utilize human iPS cells both in vitro and in vivo through xenografted mouse models of Alzheimer's disease to delve deeper into this crucial aspect of Alzheimer's pathology, which is also crucial for drug development for this debilitating condition.

For more details, refer to key references from the lab:

  • Xenografted human microglia exhibit varied transcriptomic responses to Alzheimer's disease-related amyloid-β pathology. Nat Neurosci PMID:
  • MEG3 initiates necroptosis in human neuron xenografts mimicking Alzheimer's disease. Science. 2023 Sep 15; : PMID:
  • The Cellular Phase of Alzheimer's Disease. Cell 164(4): PMID: Review.

Profile

Required

The ideal candidate:

  • Should possess a PhD in neuroscience, biology, or a related field
  • Must demonstrate creativity, enthusiasm, and critical thinking
  • Enjoys collaborative teamwork and possesses exceptional oral and written English communication skills.

Appreciated

  • Previous experience with laboratory mice
  • Skills in project management and effective communication
  • Familiarity with literature on neurodegenerative disorders
  • Understanding of non-coding RNA
  • Proficiency in the endo-lysosomal pathway
  • Previous work with iPSC cells
  • Solid publication track record

We offer

  • Highly stimulating scientific environment
  • Opportunity to mentor students and technicians while building an independent research profile
  • Access to cutting-edge infrastructure
  • A diverse, dynamic international research setting within a top-tier academic lab
  • Expertise in animal models and neurodegenerative disorders
  • Financial support guaranteed for a minimum of 2 years with the possibility of extension (one-year contract renewable). Candidates are encouraged to secure a personal fellowship (Marie-Curie, HFSP, EMBO, or from National funding organizations).
  • Immediate availability for the position - start date: as soon as possible


  • Leuven, Flandre, Belgique VIB Temps plein

    Posted Date 27 May 202 Locations Leuven Center VIB-KU Leuven Center for Brain & Disease Research Lab Bart De Strooper Lab Type Postdoctoral Positions 1Description:Additional information may be found in the following selected references from the lab:Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related...


  • Leuven, Flandre, Belgique VIB Temps plein

    The Vanderhaeghen Lab ( ; @VanderhaeghenP2) at the VIB-KU Leuven Center for Brain & Disease Research (), is seeking a creative postdoctoral scientist to study the human-specific mechanisms of development and function of cortical neurons. Join us to undertake a highly interdisciplinary project focusing on one exciting question: « What makes our brain human...


  • Leuven, Flandre, Belgique VIB Temps plein

    Posted Date 31 Jan 202 LocationsLeuvenCenterVIB-KU Leuven Center for Brain & Disease ResearchLabPierre Vanderhaeghen LabTypePostdoctoralPositions1Join us to work on a fascinating project that explores the essence of the human brain. Become part of a team where we blend advanced techniques like human corticogenesis stem cell models, human-mouse brain...

  • Postdoctoral Researcher

    il y a 1 semaine


    Leuven, Flandre, Belgique IMEC Inc. Temps plein

    Postdoctoral Researcher - Decipher The Multifactorial Aspects of Fibrosis Through Multimodal Nanotec- Research & development - Leuven | Just now- What you will doWe are looking for a researcher for Life Sciences Unit. Tissue and organ regeneration is a process that is finely tuned through the interaction of cellular and molecular events. When successful, it...


  • Leuven, Flandre, Belgique KU Leuven Temps plein

    The ideal candidate for the Research Expert position will have:PhD in Biomedicine with a minimum of 5-6 years post-doc experience in human pluripotent stem cell work in the neuroscience area, and a strong command of gene editing techniques. Extensive experience and expertise in handling and manipulating human iPS and ES cells.Proficiency in creating complex...

  • Postdoctoral Researcher

    il y a 1 semaine


    Leuven, Flandre, Belgique IMEC Inc. Temps plein

    Postdoctoral Researcher - Theory of Quantum Systems and Quantum Computers- Research & development - Leuven | Just now- What you will doWhat we do for youWe offer you the opportunity to join one of the world's premier research centers in nanotechnology at its headquarters in Leuven, Belgium. With your talent, passion and expertise, you'll become part of a...


  • Leuven, Flandre, Belgique VIB Temps plein

    Posted Date31 Jan 202 LocationsLeuvenCenterVIB-KU Leuven Center for Brain & Disease ResearchLabLynette Lim LabTypePostdoctoralPositions1Job Description:The Laboratory of Interneuron Developmental Dynamics (under Lynette Lim) is part of VIB-KU Leuven Center for Brain & Disease Research and located on Campus Gasthuisberg, Leuven, Belgium. Our main focus lies...


  • Leuven, Flandre, Belgique KU Leuven Temps plein

    You have or will have obtained (close to the starting date) a PhD in Information Systems Engineering/Informatics/Computer Science/Machine Learning/Statistics or a related discipline with a focus on process analytics, preferably with a focus on building predictive and/or prescriptive models.You have a mature publication track record with exposure in top...


  • Leuven, Flandre, Belgique VIB Temps plein

    Postdoctoral position in bioinformatics of the human gut microbiome:EmployerVIBLocationLeuvenClosing date12 Jul 2024Discipline Life Science Job Type Postdoctoral Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob Details: Profile A...


  • Leuven, Flandre, Belgique VIB Temps plein

    Posted Date 31 Jan 202 Locations Leuven Center VIB-KU Leuven Center for Brain & Disease Research Lab Bart De Strooper Lab Type Technical Support Positions 1The Laboratory for the Research of Neurodegenerative Diseases headed by Prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer's disease are...


  • Leuven, Flandre, Belgique Springer Nature Temps plein

    Postdoctoral Fellow for Laboratory of Interneuron Developmental Dynamics:EmployerVIBLocationLeuvenClosing date31 Mar 2024Discipline Life Science Job Type Postdoctoral Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob Details: Job...


  • Leuven, Flandre, Belgique Springer Nature Temps plein

    Postdoctoral Fellow for Laboratory of Interneuron Developmental Dynamics:EmployerVIBLocationLeuvenClosing date1 May 2024Discipline Life Science Job Type Postdoctoral Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob Details: Job...

  • Postdoctoral

    il y a 1 semaine


    Leuven, Flandre, Belgique VIB Temps plein

    Posted Date 17 Jun 202 Locations Leuven Center VIB-KU Leuven Center for Microbiology Lab Joleen Masschelein Lab Type Postdoctoral Positions 1Postdoctoral position on engineering microbial cell factories for the industrial production of high-value natural products:Job description:Are you interested in engineering microbial cell factories for the high-yield...

  • 2 Post-doc Positions

    il y a 1 semaine


    Leuven, Flandre, Belgique Springer Nature Temps plein

    2 Post-doc positions - heterotypic amyloid interactions:EmployerVIBLocationLeuvenClosing date17 May 2024Discipline Life Science Job Type Postdoctoral Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob Details: We recently secured...


  • Leuven, Flandre, Belgique Medpace, Inc. Temps plein

    Job Summary:We are currently seeking a full-time, office-based Patient Recruitment Coordinator to join our growing Patient Recruitment team. This position will work on a team to accomplish tasks and projects that are instrumental to the company's success. If you want an exciting career where you use your previous expertise and can develop and grow your...


  • Leuven, Flandre, Belgique IMEC Inc. Temps plein

    Research & development - Leuven | Just now Delivering inventive contributions to the development and optimization of nanostructured electrodes- What you will doThere are many puzzle pieces that are required to enable the energy transition towards a sustainable future. It is undeniable that production of renewable energy alone is not sufficient. Energy...

  • Research Associate

    il y a 1 semaine


    Leuven, Flandre, Belgique reMYND Temps plein

    reMYND is a clinical stage company developing treatments for Alzheimer's, Huntington's,epilepsy and other diseases caused by cellular dysfunction.reMYND's most advanced program is ReS19-T, an investigational compound for thetreatment of Alzheimer's, ready to start Phase 2a.Open Position: Research AssociateYour role:Supporting the expansion of reMYND's animal...


  • Leuven, Flandre, Belgique KU Leuven Temps plein

    Qualifications: Ph.D. in a relevant field such as Experimental Petrology, Mineral Physics, Planetary Sciences, Geophysics, or Computational Physics.Strong background in planetary sciences with a focus on Mercury or related fields.Experience with experimental techniques (e.g., high-pressure experiments, multi-anvil press) and/or numerical modeling and...

  • Junior Laboratory Technician

    il y a 1 semaine


    Leuven, Flandre, Belgique VIB Temps plein

    About us The Laboratory of Proteolytic Mechanisms Mediating Neurodegeneration, which is part of the VIB-KU Leuven Center for Brain & Disease Research, is committed to advancing scientific knowledge and innovation in the field of Alzheimer's disease. We are a team of (international) postdocs and PhD students interested in deciphering the molecular...


  • Leuven, Flandre, Belgique KU Leuven Temps plein

    You obtained a Master's degree in Physical Education and Movement Sciences, Rehabilitation Sciences, or in another relevant/related discipline; or you will obtain your Master's degree no later than July 2024.You are interested in scientific research and motivated to start a PhD.You are motivated to assist in the teaching assignments (e.g. practical courses)...