PhD position: exploring a shared upstream pathway as potential driver of ICU-acquired muscle weakness and adrenal insufficiency in prolonged critical illness
Il y a 2 mois
Our research focuses on critical illness, caused by sepsis, complicated surgery or extensive trauma, causing impaired organ function to the extent that the patient would die shortly when not receiving intensive medical care. Although modern intensive care has reduced mortality, a large number of survivors continue to require such supportive care in the ICU for weeks or months. Lingering unresolving organ failure then becomes the main driver of poor short- and long-term outcome irrespective of the initial diagnosis upon admission. Research from our group has focused on two of these unresolved problems, namely ICU-acquired muscle weakness and ICU-acquired adrenal insufficiency, for which there is either no treatment or treatment.
This project will address the hypothesis that ICU-acquired adrenal insufficiency and ICU-acquired muscle weakness share upstream underlying mechanisms, pathways that are currently unexplored and that can be manipulated with the potential to reverse both problems together. We will test this hypothesis via an experimental and a clinical track. We will make use of our clinically relevant mouse model of intensive-care-supported critical illness to selectively target specific molecular pathways. For translational purposes, we will also use human plasma and tissue biopsies and extensive clinical data prospectively collected.
Keywords: Critical illness, sepsis, endocrinology, inflammation, metabolism
The selected candidate will conduct translational PhD research under the supervision of Prof. Greet Van den Berghe and Prof. Lies Langouche. You will join the Intensive Care Medicine Research Group, part of the department of Cellular and Molecular Medicine at the University of Leuven (KU Leuven, Belgium). We are a multidisciplinary, translational basic/clinical research team that combines a research laboratory with a large intensive care unit (ICU). This unique combination allows effective cross-talk between knowledge generated from patient studies and from animal and molecular studies in the laboratory. We offer a doctoral position for 1 year in an interdisciplinary environment.After a positive evaluation, the position is prolonged with 3 yearsYou will work in a translational multidisciplinary research team that is internationally recognized as the expert in research integrating Intensive Care Medicine and Endocrinology/Metabolism/NutritionYou will have access to state-of-the-art research facilities and will be registered in a specific program of the doctoral school-
Leuven, Flandre, Belgique KU Leuven Temps pleinWe are looking for a highly motivated, enthusiastic, critical, and creative person with a master degree or equivalent in a relevant field, such as Medicine, Biomedical Sciences, Bioscience Engineering, Biomedical Engineering, Biochemistry, Biology (or will obtain this degree in 2024)Solid knowledge of molecular biologyPrior experience with general laboratory...
-
Leuven, Belgique KU Leuven Temps pleinWe are looking for a highly motivated, enthusiastic, critical, and creative Medical Doctor (you have or will obtain this degree in 2024) with strong interest in paediatrics.You are interested in scientific research and like to work with young people.You have good social and communicative skills, both towards the participants in the study and your...
-
Leuven, Flandre, Belgique KU Leuven Temps pleinWe are looking for a highly motivated, enthusiastic, critical, and creative Medical Doctor (you have or will obtain this degree in 2024) with strong interest in paediatrics.You are interested in scientific research and like to work with young people.You have good social and communicative skills, both towards the participants in the study and your...
-
Leuven, Belgique KU Leuven Temps pleinWe are looking for a highly motivated, enthusiastic, critical, and creative Medical Doctor (you have or will obtain this degree in 2024) with strong interest in paediatrics.You are interested in scientific research and like to work with young people.You have good social and communicative skills, both towards the participants in the study and your...
-
PhD Position on Modeling of Energy Systems and Markets
il y a 1 semaine
Leuven, Flandre, Belgique EnergyVille Temps pleinBeschrijving At the division of Applied Mechanics and Energy Conversion (TME) of the Department of Mechanical Engineering at KU Leuven, and embedded in EnergyVille, a dynamic research group led by prof. Erik Delarue is working on the modeling of energy systems and markets (unit commitment, system planning, equilibrium modeling, renewables integration,...
-
Leuven, Belgique KU Leuven Temps pleinWe seek a motivated and skilled candidate with a master’s degree in geography, anthropology, social or political sciences, tourism studies, or a related discipline. The ideal candidate:has a strong profile in socio-spatial theory and analysishas an interest in and experience with tourism geographies/anthropologyhad good academic performances on BSc and MSc...
-
PhD position
il y a 1 semaine
Leuven, Flandre, Belgique KU Leuven Temps pleinYou possess a master degree in psychology, educational sciences, business, social sciences, or related fields, with outstanding academic achievements;You demonstrate a strong interest in labor market subjects, engaging in research related to significant policy and societal issues;You are proficient in English;You find pleasure in the writing process and are...
-
Two PhD positions
il y a 2 jours
Leuven, Belgique KU Leuven Temps pleinYou have a Master’s or Research Master’s degree in Philosophy, or a Master’s or Research Master’s degree in the Humanities or Social sciences, combined with a clear indication of substantial philosophical interest and knowledge (e.g. a Bachelor’s degree in Philosophy). You must meet the requirements to be admitted to the PhD at the Institute of...
-
Leuven, Belgique KU Leuven Temps pleinWe are looking for highly motivated, enthusiastic and communicative researchers with a Master of Science degree (or PhD, if applying for post-doc) in Engineering or a related field, from a reputable institute. You should have obtained excellent study results. Candidates should have a strong interest in energy, especially in energy system operation and...
-
Leuven, Belgique KU Leuven Temps plein- An excellent curriculum with a Master’s degree in biomedical sciences or in biology, biotechnology, bio-engineering, medicine or pharmacy. - Highly motivated to study the immunology and metabolism of malaria, a major tropical infectious disease.- Eligibility and suitable profile for application for a fellowship (e.g. FWO) is an important asset.- Felasa B...
-
Disease resolution and immunometabolism in severe malaria
il y a 4 semaines
Leuven, Belgique KU Leuven Temps plein- An excellent curriculum with a Master’s degree in biomedical sciences or in biology, biotechnology, bio-engineering, medicine or pharmacy. - Highly motivated to study the immunology and metabolism of malaria, a major tropical infectious disease.- Eligibility and suitable profile for application for a fellowship (e.g. FWO) is an important asset.- Felasa B...
-
PhD position
il y a 1 semaine
Leuven, Flandre, Belgique KU Leuven Temps pleinWe expect that:you have a Master of Science in Psychology or Educational Sciences or an equivalent and relevant diploma, or you will obtain this diploma before October 1, 2024;you have achieved very good academic results (at least with distinction);you have a passion for research;you have very good writing skills in Dutch and English and/or are willing to...
-
Phd Position
il y a 1 semaine
Leuven, Flandre, Belgique Springer Nature Temps pleinPhD position - Impact of gender-affirming therapy on bone:EmployerKU LeuvenLocationLeuvenSalarynvtClosing date14 May 2024Discipline Engineering, Health Science Job Type PhD Position Employment - Hours Full time Duration Fixed term Qualification Masters Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob...
-
Erc-funded Phd Position in Molecular Genetics
il y a 3 semaines
Leuven, Belgique VIB Temps plein**ERC-funded PhD Position in Molecular Genetics**: - Employer- VIB- Location- Leuven- Closing date- 13 Jul 2024- Discipline Life Science Job Type PhD Position Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details - Company **Job...
-
Phd Position in Gut Microbial Ecology
Il y a 2 mois
Leuven, Belgique Springer Nature Temps plein**PhD position in gut microbial ecology**: - Employer- VIB- Location- Leuven- Closing date- 18 Mar 2024- Discipline Life Science Job Type PhD Position Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details - Company **Job...
-
Phd Position in Gut Microbial Ecology
il y a 3 jours
Leuven, Belgique Springer Nature Temps plein**PhD position in gut microbial ecology**: - Employer- VIB- Location- Leuven- Closing date- 18 Mar 2024- Discipline Life Science Job Type PhD Position Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details - Company **Job...
-
Phd Position in The Field of Rare Amyloidosis
il y a 2 semaines
Leuven, Belgique Springer Nature Temps plein**PhD position in the field of rare amyloidosis diseases**: - Employer- VIB- Location- Leuven- Closing date- 26 Apr 2024- Discipline Life Science Job Type PhD Position Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details -...
-
Phd Position in Gut Microbial Ecology
il y a 3 semaines
Leuven, Belgique Springer Nature Temps plein**PhD position in gut microbial ecology**: - Employer- VIB- Location- Leuven- Closing date- 18 Mar 2024- Discipline Life Science Job Type PhD Studentship Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details - Company **Job...
-
Phd Position in The Field of Rare Amyloidosis
il y a 3 semaines
Leuven, Belgique Springer Nature Temps plein**PhD position in the field of rare amyloidosis diseases**: - Employer- VIB- Location- Leuven- Closing date- 26 Mar 2024- Discipline Life Science Job Type PhD Studentship Employment - Hours Full time Duration Permanent Qualification Professional certification Sector Academia- You need to sign in or create an account to a job. - Job Details -...
-
PhD position
il y a 1 mois
Leuven, Belgique KU Leuven Temps pleinYou have a master degree in psychology or educational sciences, business sciences, social sciences or related disciplines, with excellent study results;You have a keen interest in labor market topics. You enjoy doing research related to policy-relevant and societal themes;You are fluent in English;You enjoy the writing process and you are eager to share your...
