Unraveling spatial molecular mechanisms underlying cartilage mechano-adaptation.
Il y a 2 mois
You have a PhD degree in biomedical sciences, biology, biotechnology, or equivalent, as can be derived from the PhD research topic. Candidates who do not hold a doctoral degree at the date of the application closure are encouraged to apply. Candidates with previous bioreactor experience and/or expertise in cartilage biology and osteoarthritis have an advantage. Knowledge of (spatial) omics techniques and/or bioinformatics is an asset. You are interested in cartilage mechanobiology and regenerative modeling and are prepared to support new grant applications. You have a multidisciplinary attitude. You will collaborate closely with an interdisciplinary team of PIs from human movement science, medicine, physics, chemistry, and biomedical engineering. You are attracted to technology and not afraid of engineering approaches to biomedical science. You have a strong problem-solving mindset, which will be crucial in this role. You are creative, take initiative, and are a team player. You have excellent communication and educational skills, which will be essential in this role. You are also willing to take responsibility for your work. We encourage you to apply if you are passionate about integrating cutting-edge technologies to solve complex biological questions and contributing to impactful osteoarthritis research. Conduct research on cartilage mechanobiology, more specific on the spatial transcriptomic response to loading in healthy and diseased cartilage. Design, plan, and execute experimental workflows in collaboration with senior researchers. Manage your research project and mentor junior PhD students within the team. Supervise undergraduate and master’s students. Collaborate with interdisciplinary researchers and support related projects within the group. Contribute to the preparation of research proposals and scientific publications, assisting in further developing this research area. Provide biological insights to support team projects at different scales (cell, tissue, joint levels). Contribute to teaching in the expertise area depending on the candidate’s profile. Administrative and technical support of activities within the research group.The Human Movement Biomechanics Research Group, led by Prof. Ilse Jonkers, seeks an outstanding postdoctoral researcher to join our team. This position is part of our research initiative on cartilage mechanobiology, focusing on the spatial cellular and molecular mechanisms underlying mechano-adaptation in osteoarthritis. The selected candidate will drive a project using single-cell RNA sequencing and spatial transcriptomics to map the transcriptomic landscape of articular chondrocytes, particularly how mechanical loading influences gene expression in healthy and osteoarthritic cartilage. Central to this research is our state-of-the-art multi-axial bioreactor suite, which allows us to simulate in vivo mechanical loading on human cartilage samples in vitro. This project aims to uncover key pathways involved in cartilage degeneration, contributing to developing novel therapeutic approaches for osteoarthritis.The Human Movement Biomechanics Research Group is a multidisciplinary team investigating how mechanical loading affects adaptive processes in the musculoskeletal system, specifically focusing on cartilage at cellular, tissue, and joint levels. We were the first to document abnormal mechanical loading in early-stage osteoarthritis, even before structural changes appeared on imaging. Our recent research line integrates cartilage loading with Wnt signaling and cytoskeletal function to better understand the biological responses of healthy and degenerative cartilage. Ultimately, we aim to develop mechanical loading protocols that prevent cartilage degeneration and promote tissue homeostasis. We will closely collaborate with the skeletal biology and engineering (SBE) research group and the KU Leuven Institute for Single Cell Omics.This position is initially offered for one year - but can be extended with one more year upon positive evaluation. The candidates will be encouraged to apply for personal fellowships together with the promotor.
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Leuven, Belgique KU Leuven Temps plein•Je hebt een doctoraat in de biomedische wetenschappen, biologie, biotechnologie of een gelijkwaardig diploma, zoals blijkt uit het onderwerp van je promotieonderzoek. Kandidaten die nog geen doctoraat hebben op de sluitingsdatum van de sollicitatie worden aangemoedigd om te solliciteren. •Kandidaten met eerdere ervaring met bioreactoren en/of expertise...
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Unraveling Photoresist Exposure Mechanisms in
Il y a 6 mois
Leuven, Belgique IMEC Inc. Temps pleinLeuven | Just now- Leverage advanced processing and materials characterization techniques to elucidate the mechanism responsible for printing the nanosized patterns of integrated circuits.- Micro and nano electronics are the key building blocks that enable the advanced performance of electronic devices that have permeated our everyday lives. These...
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Leuven, Belgique KU Leuven Temps pleinA PhD in bioinformatics, computational biology, or a related field.Extensive experience in bioinformatics analysis, including statistical and computational approaches.Programming skills in R, Python, Matlab, or similar languages.A strong interest in immunology and experience with large-scale data analysis.Experience with machine learning approaches is an...
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Leuven, Belgique KU Leuven Temps pleinPhD in computer science, physics, mathematics or a related field.Experience in the analysis of single-cell and/or spatial omics data.Proficient in at least one modern programming language such as Python, Julia, and R.Excellent analytical, technical, and problem solving skills.Strong organizational and time management skills; capable of handling multiple...
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Group Leader Functional Cancer Genomics
Il y a 2 mois
Leuven, Belgique VIB Temps pleinThe **VIB Center for Cancer Biology (CCB) **and the KU Leuven department of **Cellular and Molecular Medicine (CMM)**, are recruiting a group leader in Functional Cancer Genomics at located at the Campus Gasthuisberg in Leuven, Belgium. The **VIB Center for Cancer Biology **(CCB) currently hosts more than 240 scientists in 14 independent research groups and...
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Erc-funded Bioinformatics Postdoc: Unravelling The
il y a 2 semaines
Leuven, Belgique VIB Temps plein**Who we are**: The lab for Systems Biology of Kevin Verstrepen is a research team at the VIB-KU Leuven Center for Microbiology. Our team focuses on genomics, genetics, epigenetics, transcriptomics and evolution, using yeast as a model. We combine wet lab and computational research to investigate how biological systems work and evolve and use this knowledge...
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Postdoctoral Position in Bio-informatics to Unravel
il y a 4 semaines
Leuven, Belgique VIB Temps pleinWhen cancer cells leave the primary tumor to seed in other organs, they need to seek the help of different cell types in distinct environments to make their journey successful. Lymph nodes (LN), which counterintuitively are centers for T-cell-antigen priming, are the first metastatic relay before cancer cells disseminate to distant organs. Thereby,...
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Leuven, Belgique KU Leuven Temps pleinYou are a highly motivated, enthusiastic and independent person with a curious, yet critical, scientific mindset, and a strong interest in plant molecular biology, genetics, and biotechnology. You are creative, maintain strong self-discipline and have a problem-solving attitude. Furthermore you have the capacity to work at the crossroads of several...
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Junior Lab Technician in Mass Spectrometry Imaging
Il y a 2 mois
Leuven, Belgique VIB Temps plein**VIB** is an entrepreneurial and vibrant non-profit research institute in Flanders-Belgium with a clear focus on groundbreaking research in life sciences. About 1500 scientists and technologists from over 60 countries are based at the 5 Flemish Universities of Ghent, Leuven, Antwerp, Brussels and Hasselt, and are studying the broad spectrum of molecular...
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Laboratory Technician
Il y a 2 mois
Leuven, Belgique VIB Temps plein**About the lab**: The **Laboratory of Neuronal Communication**, led by Prof. **Patrik Verstreken**, is part of the **VIB-KU Leuven Center for Brain & Disease Research** at Gasthuisberg Campus (**Leuven**, Belgium). We are a team of more than 30 international scientists/ admin. staff interested in understanding the molecular mechanisms of healthy **synaptic...
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Leuven, Belgique KU Leuven Temps pleinMaster degree in quantitative sciences (statistics, mathematics, physics, etc.).Extensive knowledge of statistics.Good presentation skills.Interests in developing new statistical methodology to address clinically relevant research questions.Good prior study results.Proficiency in English (orally and written).Background: Osteoarthritis (OA) is a degenerative...
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Leuven, Belgique KU Leuven Temps pleinMsc in data science-adjacent fields (biostatistics, bioinformatics, computer science, bioengineering, biotechnology).Background:Implementation, training and benchmarking of deep neural networks (PyTorch experience is a plus) .Experience in molecular biology is a plusExperience in single-cell transcriptomics analysis is a plusExperience with communication to...
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Leuven, Belgique KU Leuven Temps pleinIf you are highly motivated researchers in the areas of Chemical Engineering with passion in separation technology for sustainability, you are strongly encouraged to enquire and apply.Profile required:Requirement: Master's degree in Chemical Engineering or in relevant disciplines, with first class honour / high distinction.Strong interest and solid...
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Regulatory Officer
Il y a 2 mois
Leuven, Belgique Mega Group International S.A. Temps pleinMega is looking for a passionate** Regulatory Manager**, keen to help Mega develop its Legal & Regulatory department for our activities in Belgium and take it to the top! Excellent communicator, rigorous, hands-on, passionate about the energy market? Are you motivated to develop within a fast-growing group? Do you have 5 years' experience as a regulatory...
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Ai Communications Specialist
il y a 1 mois
Leuven, Belgique IMEC Inc. Temps pleinMedia, Communications and Writing - Leuven | Just now- As AI Communication Specialist of the Flanders AI Research Program, you are responsible for the development and roll out of the communication strategy. With appealing dissemination of latest AI research results, we invite companies and organizations to engage in collaborative research projects and to...
