Senior Scientist, LC-MS Proteomics

Senior Scientist, LC-MS Proteomics
VIB
Ghent, Belgium

Your Role

• You independently operate state-of-the-art high-resolution LC-MS/MS platforms, such as Orbitrap and/or timsTOF instruments, coupled to nanoLC and/or microLC systems;
• You develop, optimize, implement and execute LC-MS/MS methods, including LC gradients, MS acquisition parameters and full analytical workflows;
• You take ownership of instrument performance and quality control, including tuning, calibration, routine maintenanceand troubleshooting, in order toproactively intervene withperformance deterioration before it impacts research projects;
• You carefully document experimental procedures, instrument performance, data and results, and work according to applicable SOPs and quality guidelines;
• You contribute to the continuous improvement of existing workflows and to the development and implementation of state-of-the-art LC-MS and proteomics applications;
• You stay up-to-date with emerging technologies and developments in LC-MS driven proteomics.

Your qualifications

Essential

• BSc, MSc or PhD in analytical chemistry, industrial sciences, biochemistry, biotechnology, biomedical sciences, molecular biology, or a related field;
• At least 5 years of relevant hands‑on LC-MS/MS experience;
• Strong practical experience with high-resolution mass spectrometry platforms, such as Orbitrap and/or timsTOF, coupled to nanoLC and/or microLC systems;
• Demonstrated ability to independently operate LC-MS/MS instrumentation, including tuning, calibration, acquisition method setup, routine maintenance, monitor instrument performance and troubleshooting;
• Experience in LC-MS/MS method development and optimization, including LC gradients, MS acquisition parameters and complete analytical workflows;
• Basic working knowledge of proteomics data analysis and search-engine tools, including protein/peptide identification, quantification, quality control and interpretation.

Desirable

• Practical experience with proteomics sample preparation;
• Experience with post‑translational modification (PTM) analysis;
• Experience with multiplexed quantitative proteomics approaches;
• Experience with intact protein measurements and characterization;
• Experience with targeted proteomics;
• Knowledge of statistical analysis and quantitative interpretation of proteomics data;
• Experience working in a core facility or service‑oriented scientific environment.

Key personal characteristics

• Hands‑on, proactive and solution‑driven;
• Strong analytical and problem‑solving skills;
• Meticulous, organized and committed to delivering reliable, high‑quality results;
• Scientific curiosity and eagerness to learn and implement new technologies;
• Independent team player;
• Service‑oriented mindset;
• Comfortable working in an international setting: fluent in English.