Associate Scientist I, Discovery-Oncology

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

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Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Pharmacology Job Category: Scientific/Technology All Job Posting Locations: Beerse, Antwerp, Belgium

Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Senior Scientist, in Oncology Discovery, Innovative Medicine, located in Beerse, Belgium Join our Oncology In Vivo team and drive the characterization and development of small molecules, biologics, radioligands, antibody-drug conjugates, cell therapies, and immune modulators for cancer treatment, coordinating cross‑functional teams and ensuring compliance with regulatory requirements. You will contribute to in vivo and ex vivo studies across multiple research programs and contribute to the advancement of innovative therapies. Specifically, you will establish and perform in vivo model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in various cancer models.

Key Responsibilities

• Design, perform, interpret and report complex in vivo preclinical cancer models.
• Conduct methods of in in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
• May contribute to ex vivo analysis of tumor cells or immune cells by FACS, IHC or ELISA, RT-PCR, or Luminex®.
• May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models.
• Analyze using appropriate statistical methods and present data in a clear presentation‑ready format.
• Analyze and present data in a clear presentation‑ready format.
• Manage multiple in vivo experiments simultaneously.
• May contribute on various projects outside of their own, or collaborate with partners from relevant functions.
• Act as a resource on project teams with clear and professional verbal and written communication.
• Some weekend, evening, and holiday dosing/ animal monitoring required.

Qualifications

• Bachelor’s degree (B.S./B.A.) in the life sciences (molecular/ cellular biology, biochemistry, pharmacology, tumor immunology) with at least 3 years of relevant pharmaceutical or biotech industry/ lab/ academic experience
• Master’s degree (M.S.) with at least 2 years of relevant pharmaceutical or biotech industry /lab/ academic experience is required
• Associate’s degree (A.S.) with at least 5 years of relevant pharmaceutical or biotech industry /lab/ academic experience is required
• Ability for cell culture of cancer or immune cells is preferred
• Experience with oncology -relevant models including xenografts, syngeneic models, primary grafts, orthotopic models, transgenics or genetically engineered tumor models is required
• Experience with small molecules and/ or biologics is desirable
• Experience with immune‑modulatory agents, vaccines or cell therapies such as CAR‑Ts is desirable
• Skills in