Post-Doc in Computational Genomics and High-throughput Genome Editing
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Post-Doc in Computational Genomics and High-throughput Genome Editing
VIB
Leuven, Belgium
About the role
We are seeking an enthusiastic and highly motivated Postdoctoral Researcher with a strong computational background to join our collaborative and interdisciplinary team. The successful candidate will join an exciting research project exploring how synonymous mutations, often assumed to be silent, shape gene expression and cellular phenotypes. Leveraging large-scale synonymous saturation mutagenesis libraries and a powerful suite of reporters already established in the lab, we systematically measure the impact of thousands of mutations across multiple molecular layers, from RNA and protein abundance and stability to protein function and cellular fitness. By integrating these complementary readouts, we aim to uncover the mechanisms through which synonymous sequence variation influences biological function. Your role will be to turn these rich, multidimensional datasets into biological insights. Working closely with experimental researchers, you will have the opportunity to develop and apply innovative computational approaches to identify patterns, uncover underlying mechanisms, and build predictive models linking genetic variation to molecular and cellular phenotypes. The project offers considerable freedom to explore new ideas and shape the computational direction of the research.
Your profile
- You have a PhD in computational biology, bioinformatics, systems biology, genomics, computer science, or a related quantitative field.
- You have demonstrated experience in analyzing and integrating complex large-scale datasets and extracting biological insights.
- You have experience with advanced computational and statistical approaches, ideally including machine learning and/or artificial intelligence. Prior experience with high-throughput mutagenesis data is an advantage but not a must.
- You have a genuine passion for science and enthusiasm for tackling challenging biological questions.
- You are a self-motivated, kind and inclusive team player who works well in a collaborative, international environment.
- You have excellent spoken and written English skills (English is our working language).
Deadline 15 December
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