Post-Doc in Computational Genomics and High-throughput Genome Editing VIB-KU Leuven Center for Microbiology
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About the role
We are seeking an enthusiastic and highly motivated Postdoctoral Researcher with a strong computational background to join our collaborative and interdisciplinary team. The successful candidate will join an exciting research project exploring how synonymous mutations, often assumed to be silent, shape gene expression and cellular phenotypes. Leveraging large-scale synonymous saturation mutagenesis libraries and a powerful suite of reporters already established in the lab, we systematically measure the impact of thousands of mutations across multiple molecular layers, from RNA and protein abundance and stability to protein function and cellular fitness. By integrating these complementary readouts, we aim to uncover the mechanisms through which synonymous sequence variation influences biological function. Your role will be to turn these rich, multidimensional datasets into biological insights. Working closely with experimental researchers, you will have the opportunity to develop and apply innovative computational approaches to identify patterns, uncover underlying mechanisms, and build predictive models linking genetic variation to molecular and cellular phenotypes. The project offers considerable freedom to explore new ideas and shape the computational direction of the research.
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