Senior Scientist

il y a 2 semaines


Gent, Flandre, Belgique Obulytix Temps plein
At Obulytix , we engineer and develop a groundbreaking new class of enzyme-based antibiotics to combat the ongoing antimicrobial resistance crisis. Apply today and help to make the difference, or refer a friend  
As Senior Scientist Protein Sciences , you will leverage your industry experience in expression, purification and characterization of therapeutic proteins to enhance Obulytix's discovery and development capabilities. Obulytix is a young biotech, providing an exciting and dynamic environment where growth opportunities abound. As an employee in a small but enthusiastic team, you are not just a number. We are supported by corporate and venture capital, and are focused on building the best possible team culture from our home base in Ghent – one of Belgium's foremost biotech clusters . 
Senior Scientist, Discovery (Protein Sciences) 
2-year fixed term contract - On-site - Full-time - Mid-Senior level 
 
Production and purification of lysins, from microtiter plate through shake flask cultures and up to small-scale fermentation (1-10L scale), to produce high-quality protein samples for biophysical and functional characterization 
Lysin characterization using standard techniques (purity by SDS-PAGE, Western Blot, SEC, Tm, Tagg, DLS and mass spectrometry in-house or through partners) 
Expression, purification and QC of tool proteins for assay development 
Work independently to design, carry out and interpret experiments, keeping up to date with relevant literature and techniques 
Independently perform quality control on experimental data, interpretation and reporting thereof 
Contribution to cross-functional project teams, preparing and presenting work and project updates 
Work closely with the rest of the Discovery Team as required, to deliver solutions or improvements in recombinant protein production and biophysical characterization 
As line manager of Protein Sciences group, educate and provide guidance as well as coaching to members of staff. Provide timeline and budget planning input and reports to Operational Lead 
PhD in a relevant biological discipline or BSc/MSc with significant (
~3y) relevant industrial experience 
~ Laboratory experience in an industrial setting required 
~ Expertise in the design of experiments, interpretation of data and troubleshooting is essential 
~ Working knowledge of a broad range of purification techniques, such as affinity (IMAC, SEC, RP, HIC & IEX) 
Experience with Cytiva ÄKTA protein purification platform with practical knowledge of Unicorn software preferred 
Solid background in protein chemistry, structure and function 
Demonstrated ability to independently design experiments, interpret data and troubleshoot any issues arising 
A team player with a flexible and collaborative working ethos towards colleagues and teams within the company, as well as with external advisors, service providers and collaborators 
Excellent abilities in record keeping and maintenance of clearly written laboratory notebooks to a standards required for publications and patent filings 
Excellent written and verbal communications skills and ability to clearly present complex data in English 
Enthusiastic, self-motivated and proactive attitude towards protein science and Drug Discovery
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