(Senior) Associate Scientist Discovery and
Il y a 5 mois
**About Johnson & Johnson**
At Johnson & Johnson Innovative Medicine, Communicable Disease unit our goal is to build new innovative products addressing key public health challenges and this includes building robust external engagements with key public and private institutions across the world.
Communicable Disease unit is committed to developing novel antibiotics for tuberculosis and build on the success of bedaquiline, a groundbreaking drug developed by Janssen for multidrug-resistant tuberculosis (MDR-TB). Tuberculosis is the leading cause of death from a single pathogen and the biggest contributor to AMR-related death. At Communicable Disease we face tuberculosis pandemia from multiple angles by trying to develop new technologies that would benefit patients compliance and would help to achieve a simpler, shorter and safer treatment for MDR-TB patients.
This position is linked with a VLAIO O&O project that will explore de discovery and characterization of fix dose combinations (FDC) for MDR-TB treatment. The work will be performed together with the University of Leuven (KUL) where they will explore new potential strategies for FDC.
We are looking for a highly motivated and innovative scientist, who will take ownership in our Discovery-Translational team in Beerse, Belgium.
The Associate Scientist will mainly develop, conduct and manage in vitro assays/models with M. tuberculosis to evaluate the efficacy of new anti-tuberculosis compounds, alone and in combination. They will also assist with the various M. tuberculosis molecular biology needs of the project. All this is done in a team-oriented, result driven, international research environment that provides an excellent career opportunity for an enthusiastic and motivated Scientist.
**Responsibilities**:
- Develop, optimize, validate and perform in vitro M. tuberculosis microbiological assays.
- Perform and report in vitro M. tuberculosis kill kinetic assays, MIC and synergy assays.
- Manage, conduct and report in vivo efficacy and PK studies of the fix dose combinations.
- Maintenance of bacterial and compound stocks.
- Establish an understanding of the relevance of the data being generated on the project.
- Present own work confidently, internally and with the project partners, with clear rationale and produce slides on own work.
- Write up lab book to department and patent-acceptable standard.
- Use appropriate scientific literature to plan assays.
- Maintain awareness of the relevant scientific literature and contemporary laboratory practices.
**Qualifications**:
The following are minimum requirements related to the Associate Scientist position.
- MSc in a relevant Biotechnology, Microbiology, Biochemistry or related; with at least 3 years of experience in industry setting or equivalent.
- Experienced in different microbiology techniques, such us culture, stocks mainteinance, molecular techniques and compound efficacy assessment. Work experience with mycobacteria would be a plus.
- Experience working in a Biosafety level 3 is preferred.
- Lab experience working with mice and having the corresponding accreditation (FELASA B).
- Proficient in English.
- Proficient in MS Office and Graphpad Prism.
- Demonstrated ability to analyze and interpret data and reporting the results.
- Demonstration of robust oral and written communication skills. Shown ability to collaborate, empathize with team members of different backgrounds required.
- Ability to work well in a quick paced, dynamic and interactive environment is vital. Excellent interpersonal skills and ability to work under pressure.
Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.
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