Pharmacometrician
Il y a 2 mois
The argenx Quantitative Pharmacology and Pharmacometrics group (QCP²) looks for an experienced pharmacometrician to support the development and execution of population pharmacokinetic [PK] and pharmacodynamic [PD] modeling and simulation activities related to the research, design, implementation, data analysis, interpretation, reporting, and publication of studies for products in any phase of development.
The pharmacometrician participates in project, including cross-functional team meetings. He/she will report to the head Quantitative Pharmacology and Pharmacometrics.
Key Accountabilities/Responsibilities:
Within the area of modeling and simulation:
Under mínimal supervision:
- Conducts advanced pharmacokinetic (PK)/pharmacodynamic (PD) modeling and simulation research with emphasis on mechanism-based modeling techniques, systems biology and disease progression models.
- Supports product development by defining dose-concentration-pharmacological effect relationships of a drug using modeling & simulation methodologies from data acquired at various development stages (Phase 1-3).
- Performs population PK/PD analyses in support of regulatory submissions.
- Develops & reviews study designs, writes analysis plans & reports, analyses and interprets PK/PD data and results.
- Maintains liaisons within and outside the organization. Represents the organization on scientific matters within the worldwide scientific community.
- Identifies opportunities and ways to address drug development questions/issues.
Desired skills and Experience:
- PhD or equivalent in Pharmaceutical Sciences, Clinical Pharmacology, Chemical/Biomedical Engineering or Biological Sciences. With minimum 5-10 years of pharmaceutical development experience in the various aspects of modeling and simulation.
- In-depth knowledge of clinical pharmacokinetics and PK/PD modeling and simulation principles.
- Fluent in written and spoken English
- Good written and oral communication skills
- Ability to build and maintain effective working relationships inside and outside the department; ability and willingness to work in a cross-functional team environment (building strategic working relationships).
- Ability to multi-task and prioritize assignments, establishing courses of action for self and others to ensure that work is completed efficiently and in a timely manner (planning, organizing and time management)
- Ability to translate creative and innovative approaches into the solution of problems and the timely advancement of projects
- Self-motivated with the ability to work independently with mínimal supervision (personal accountability)
- A thorough knowledge of the clinical development process
- Ability to drive alignment around his/her vision and strategy across departments
- Excellent knowledge in the pharmacokinetics of mAb based therapeutics and solid understanding of translational sciences
- Flexible, deal with continuous change
**Offer**:
- A competitive salary package with benefits;
- A work environment in a human-sized, dynamic, rapidly growing biotech company.
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