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Phd: Linking Neurodevelopment and Mitochondria in
Il y a 4 mois
**PhD: Linking neurodevelopment and mitochondria in human neurons using iPSC and xenotransplantation**:
- Employer- VIB- Location- Leuven- Closing date- 7 Jul 2024- Discipline
Life Science
Job Type
Research Assistant
Employment - Hours
Full time
Duration
Permanent
Qualification
Professional certification
Sector
Academia- You need to sign in or create an account to a job.
- Job Details
- Company
**Job Details**:
**PhD position: Linking neurodevelopmental disorders and mitochondria in human neurons, using iPSC and xenotransplantation** We are looking for an ambitious PhD student with a broad interest in interdisciplinary research working in the exciting field of Neuroscience.**Project** While most genes associated with neurodevelopmental disorders (NDD) encode proteins involved in transcriptional/epigenetic regulation or synaptic function, increasing evidence suggests that mitochondria dynamics or function may be affected in at least some of these conditions.
- Among NDD potentially linked to mitochondria are Rett syndrome (RTT) and MECP2 duplication syndrome, both caused by abnormal dosage of MECP2 protein. We have developed a xenotransplantation model for both disorders, as well as novel ways to investigate the mitochondrial phenotypes in human diseased neurons (_Nageshappa et al. _Mol Psychiatry. (2016);21(2):178-88; _Linaro et al. Neuron (2019) 104(5):972-986; Iwata et al. Science (2023) 379: 1-9 science.abn4705). _Here we will explore whether and how mitochondrial abnormalities contribute to the neurological pathology in human neurons in vitro and in vivo. This project will lead to novel insights into NDD mechanisms and potentially to innovative therapeutic venues.**Profile**
- and Genebiotechnology), Neuroscience,..).
- Previous research experience, especially regarding cell culture is a plus, but not essential.
- English is the main language and proficiency in written and spoken English is crucial.
- You are a good writer, and you are not afraid of public speaking (e.g., delivering a conference presentation,...)
**We offer**
- The possibility to participate in international conferences and collaborations.
- Doctoral training at the Leuven International Doctoral School of Biomedical Sciences
Please use the VIB HR Application tool.
Additional required information:
- detailed CV
- motivation letter describing your previous research experience
- names and contact information of at least 2 references
For more information or informal inquiry please contact:
**Company**:
**Company info**
- Website-
- Telephone- 09446611- Location- Rijvisschestraat 120
- Zwijnaarde
- Belgium
- 9052
- BE
