Associate Scientist in Vivo
il y a 1 semaine
Your key responsibilities:
- Conduct methods of in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
- Conduct in vitro human and ex vivo mouse immunology experiments to support ongoing immune-oncology portfolio including assays using cancer cell, myeloid and T-cell based co-cultures. Tumour cell biology analysis including analysis of PDX lines and tumour dissociated material.
- Assist with design, execution, interpretation and reporting for in vivo syngeneic tumour model studies, to analyse efficacy of both intra-tumoral and systemic interventions.
- Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements.
- Application of diverse expertise in cellular and molecular biology (e.g. cell/organoid culture, compound screening, FACS, ELISA, western blotting, qRT-PCR, cell transfections & transductions, viral productions).
- Support discovery biology team with experimental set-up, assay optimization, analyze data using appropriate statistical methods and preparing data for presentation-ready format.
Required Qualifications
- A minimum of a Bachelor’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) with a minimum of 3 to 5 years of relevant laboratory-based experience in industry/biotech or an academic setting is preferred. OR a Master’s degree (M.S.) with relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
- Experienced with animal handling in oncology-relevant rodent models such as subcutaneous and orthotopic tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
- Experience with the adherence to animal welfare and compliance regulations is required.
- Drug administration by subcutaneous, intraperitoneal, intravenous tail vein injections and oral gavage. Blood collection by tail vein, saphenous vein and cardiac puncture. Perform animal autopsy/dissection and microsurgery, perfusion and tissue collection.
- Experienced with cell culture of cancer or immune cells is preferred.
- Experienced with bioluminescent imaging, flow cytometry, IHC, ELISA is preferred.
- This position may require occasional weekend, evening, and holiday dosing/animal monitoring.
Other Requirements
- Must have excellent interpersonal skills, with the ability to interact effectively with people.
- Must have strong organizational, data management, and record-keeping skills.
- The ability to handle several projects simultaneously is preferred.
- Must have excellent verbal and written communication skills in English
- Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
- Knowledge of Microsoft Office and Graphpad Prism.
- Learning agility and ability to work across projects highly desirable
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