Postdoc Position: Single-cell Regulatory Genomics of Human Brain Evolution
il y a 5 jours
**Postdoctoral position to study species-specific mechanisms of gene regulation in human neurons.**
Join us to undertake a highly timely interdisciplinary project focusing on a long-standing and fascinating question : « what makes our brain cells human ? » (see our recent work : Hecker et al. Science 2025; Libé-Philippot et al. Cell 2023; Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023).
You will explore single-cell epigenomics and transcriptomics data, focused on the neurons of the cerebral cortex from human and an array of non-human species. Using computational and machine learning approaches, you will decipher genomic regulatory programs and infer the evolutionary patterns of gene regulatory networks in cortical neurons, study their developmental origin, and predict their impact on species-specific properties of human neurons. This highly multidisciplinary project will be undertaken in active collaboration with our two labs, at a unique interface of top-notch computational biology and neurosciences.
**_See more in selected references from our labs: _**
- Hecker et al. (2025) Science 387, eadp3957_
- Taskiran et al. (2024) Nature 626, 212-220_
- Libé-Philippot et al. (2023) Cell 186, 5766-5783_
- Iwata et al. (2023) Science 379, eabn4705_
- Vanderhaeghen P, Polleux F. (2023) Nat. _Rev. Neurosci. 24, 213-232_
**Profile**:
We are seeking highly motivated individuals with a strong interest in neurobiology and/or evolutionary biology, with a strong background in bioinformatics.
- PhD in Bioinformatics, Engineering, Computer Science, Physics, Bio-engineering, or Life Sciences
- Programming skills in Python
- Experience with Machine learning (PyTorch/Keras).
- A computational mindset and a strong interest in computational biology
**We offer**:
- A versatile and challenging job with very diverse contacts in a world-class research environment operating at an international level and various opportunities to broaden your expertise
- A competitive compensation package based on expertise and experience
- Starting Date: as soon as possible
**How to apply?**:
-
Leuven, Belgique WhatJobs Temps pleinTwo AI postdoc or machine learning engineer positions for oncology research KU Leuven is an autonomous university. It was founded in 1425. It was born of and has grown within the Catholic tradition. Located at the Gasthuisberg campus in the picturesque city of Leuven, the Laboratory of Cell Stress & Immunity (Department of Cellullar & Molecular Medicine) and...
-
Leuven, Belgique VIB Temps plein**About the labs**: The Verstreken Lab and the Gonçalves Lab are based in Leuven, Belgium and part of the VIB-KU Leuven Center for Brain & Disease Research, and NERF and VIB.AI, respectively. The Verstreken lab is developing advanced multielectrode array systems to mimic human brain circuits relevant to Parkinson’s disease, and has been supported by the...
-
Bioinformatician Postdoctoral Level
il y a 5 jours
Leuven, Belgique VIB Temps plein**Position summary**: **Profile**: **Essential Requirements** - PhD in Bioinformatics, Computational Biology, Statistics, Computer Science, Genetics, or equivalent. - Proficiency in Python and/or R, with a solid grasp of statistics. - Excellent organizational and time management skills, with a flexible mindset for acquiring new skills. - Ability to work...
-
Phd Student Position in Systems Neuroscience
il y a 5 jours
Leuven, Belgique VIB Temps pleinThis position is a joint effort between the laboratories of Vincent Bonin and Karl Farrow at NERF, and is part of a broader collaboration with Pierre Vanderhaeghen (VIB-KU Leuven) and Franck Polleux (Columbia University). **Research Project**: **“Linking human-specific synaptic developmental timing to early cortical circuit function and plasticity in...
-
Postdoctoral Fellow
il y a 5 jours
Leuven, Belgique VIB Temps plein**Research Project**: “Linking human-specific synaptic developmental timing to early cortical circuit function and plasticity in ASD” This project addresses a compelling hypothesis: that disruption in the uniquely human prolonged timeline of synapse development—synaptic neoteny—contributes to ASD. The project will explore how SYNGAP1...
-
Leuven, Belgique VIB Temps pleinWhen cancer cells leave the primary tumor to seed in other organs, they need to seek the help of different cell types in distinct environments to make their journey successful. Lymph nodes (LN), which counterintuitively are centers for T-cell-antigen priming, are the first metastatic relay before cancer cells disseminate to distant organs. Thereby,...
-
Postdoc in Carbon Fixation Mediated By Marine
il y a 5 jours
Leuven, Belgique VIB Temps plein**Job description**: This is a starting lab, meaning the postdoc will get significant hands-on time with brand-new mass spectrometers and other cutting-edge equipment, and will play a prominent leadership role in shaping the lab environment. The postdoc should be open to working in interdisciplinary collaborations to broaden their scientific network and...
-
Leuven, Belgique VIB Temps plein**About the lab**: **Job description**: **What we’re looking for** - Hands-on experience in one or more of the following: CRISPR/Cas systems, high-throughput screening, FACS, genomics, bioinformatics. - A passion for science. - Self-motivated, kind and inclusive team players who work well in a collaborative, international environment. Excellent spoken and...
-
Leuven, Belgique VIB Temps pleinWe have discovered that vascular/immunomodulating therapies can transform immunosuppressive tumor endothelial cells into immune-stimulating high-endothelial venules (HEV) that due to their specific functions, lead to substantial T and B cell infiltrates, reminiscent of tertiary-lymphoid structures (TLSs) (Allen E. et al Sci Transl Med 2017, Hua et al. Cancer...
-
Leuven, Belgique KU Leuven Temps pleinThe KU Leuven Life Cycle Engineering (LCE) research group in the Department of Mechanical Engineering and the KU Leuven Institute for Sustainable Metals and Minerals (SIM2) has developed strong, unique expertise in reuse, repair, repurposing, remanufacturing, and recycling, in close cooperation with its industrial partners. To support these research...