Postdoc Position: Single-cell Regulatory Genomics of Human Brain Evolution
il y a 1 semaine
**Postdoctoral position to study species-specific mechanisms of gene regulation in human neurons.**
Join us to undertake a highly timely interdisciplinary project focusing on a long-standing and fascinating question : « what makes our brain cells human ? » (see our recent work : Hecker et al. Science 2025; Libé-Philippot et al. Cell 2023; Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023).
You will explore single-cell epigenomics and transcriptomics data, focused on the neurons of the cerebral cortex from human and an array of non-human species. Using computational and machine learning approaches, you will decipher genomic regulatory programs and infer the evolutionary patterns of gene regulatory networks in cortical neurons, study their developmental origin, and predict their impact on species-specific properties of human neurons. This highly multidisciplinary project will be undertaken in active collaboration with our two labs, at a unique interface of top-notch computational biology and neurosciences.
**_See more in selected references from our labs: _**
- Hecker et al. (2025) Science 387, eadp3957_
- Taskiran et al. (2024) Nature 626, 212-220_
- Libé-Philippot et al. (2023) Cell 186, 5766-5783_
- Iwata et al. (2023) Science 379, eabn4705_
- Vanderhaeghen P, Polleux F. (2023) Nat. _Rev. Neurosci. 24, 213-232_
**Profile**:
We are seeking highly motivated individuals with a strong interest in neurobiology and/or evolutionary biology, with a strong background in bioinformatics.
- PhD in Bioinformatics, Engineering, Computer Science, Physics, Bio-engineering, or Life Sciences
- Programming skills in Python
- Experience with Machine learning (PyTorch/Keras).
- A computational mindset and a strong interest in computational biology
**We offer**:
- A versatile and challenging job with very diverse contacts in a world-class research environment operating at an international level and various opportunities to broaden your expertise
- A competitive compensation package based on expertise and experience
- Starting Date: as soon as possible
**How to apply?**:
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Leuven, Belgique VIB Temps pleinJoin us to undertake a highly interdisciplinary project focusing on a long-standing and fascinating question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse brain xenotransplantation, mouse transgenesis, in...
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