Senior Scientist, LC-MS Proteomics

VIB (Vlaams Instituut voor Biotechnologie) is a renowned life sciences research institute in Belgium, committed to conducting groundbreaking research in life sciences and biotechnology with an excellent reputation in technology transfer. The unique combination of strategic basic research and a clear focus on innovation & business is one of the major contributors to its success. VIB is highly committed to being the driving force behind the growth of the dynamic life sciences cluster in Flanders. VIB Technologies constitutes the centralized scientific research infrastructure of the institute and allows scientists access to high-end and innovative technologies. VIB Technologies comprises multiple state-of-the-art core facilities, each with a specific technology focus and embedded within the VIB premises in Ghent, Leuven, Antwerp and Brussels. The role of these core facilities is to support the 1900 researchers at VIB with their expertise. Within VIB Technologies we have over 130 staff members. The Proteomics Core offers advanced, mass spectrometry–based technologies for comprehensive proteome and protein analysis. The core supports projects including, but not limited to large-scale and comprehensive proteome profiling including mapping of protein modifications to targeted quantification, protein interaction mapping, low-input and chemical proteomics. Throughout the process—from sample preparation to data analysis and interpretation—we provide guidance and expertise to ensure clear, actionable biological insights for all users. The Proteomics Core is currently seeking a new Senior Scientist and welcomes applications from proteomics experts around the globe. Your Role You independently operate state-of-the-art high-resolution LC-MS/MS platforms, such as Orbitrap and/or timsTOF instruments, coupled to nanoLC and/or microLC systems You develop, optimize, implement and execute LC-MS/MS methods, including LC gradients, MS acquisition parameters and full analytical workflows You take ownership of instrument performance and quality control, including tuning, calibration, routine maintenanceand troubleshooting, in order toproactively intervene withperformance deterioration before it impacts research projects You carefully document experimental procedures, instrument performance, data and results, and work according to applicable SOPs and quality guidelines You contribute to the continuous improvement of existing workflows and to the development and implementation of state-of-the-art LC-MS and proteomics applications You stay up-to-date with emerging technologies and developments in LC-MS driven  proteomics Your qualificationsEssential BSc, MSc or PhD in analytical chemistry, industrial sciences, biochemistry, biotechnology, biomedical sciences, molecular biology, or a related field At least 5 years of relevant hands-on LC-MS/MS experience Strong practical experience with high-resolution mass spectrometry platforms, such as Orbitrap and/or timsTOF, coupled to nanoLC and/or microLC systems Demonstrated ability to independently operate LC-MS/MS instrumentation, including tuning, calibration, acquisition method setup, routine maintenance, monitor instrument performance and troubleshooting Experience in LC-MS/MS method development and optimization, including LC gradients, MS acquisition parameters and complete analytical workflows Basic working knowledge of proteomics data analysis and search-engine tools, including protein/peptide identification, quantification, quality control and interpretation Desirable Practical experience with proteomics sample preparation Experience with post-translational modification (PTM) analysis Experience with multiplexed quantitative proteomics approaches Experience with intact protein measurements and characterization Experience with targeted proteomics Knowledge of statistical analysis and quantitative interpretation of proteomics data Experience working in a core facility or service-oriented scientific environment Key personal characteristics Hands-on, proactive and solution-driven Strong analytical and problem-solving skills Meticulous, organized and committed to delivering reliable, high-quality results Scientific curiosity and eagerness to learn and implement new technologies Independent team player Service-oriented mindset Comfortable working in an international setting: fluent in English

We offer
A full-time position with an open-ended contract Access to state-of-the-art infrastructure and in-house training A challenging job in a stimulating, collaborative environment with opportunities for personal development Exposure to diverse projects and cutting-edge technologies A competitive salary and benefits A generous ann