Senior Manager, Internal Controls

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. agenix is preparing for multi‑dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first‑in‑class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases. We are building a new kind of biotech company, one that maintains its roots as a science‑based start‑up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. PURPOSE OF THE FUNCTION Lead the execution and continuous evolution of argenx's SOX framework across Financial Reporting & Consolidation and Tax cycles, ensuring a risk‑based control environment that supports reliable financial reporting and scalable growth. Partner with Finance and the business to embed effective controls into strategic initiatives and digital solutions, while coordinating cycle‑specific Internal Audit and External Audit activities and promoting a strong culture of risk awareness and control ownership. ROLES AND RESPONSIBILITIES SOX Compliance Lead the end‑to‑end SOX program for and drive the scalable evolution of the Financial Reporting & Consolidation and Tax cycles, ensuring ICFR effectiveness in accordance with Section404 of the Sarbanes‑Oxley Act of 2002 and related SEC rules and regulations. Drive SOX scoping and risk assessment activities, partnering with Finance and business stakeholders to design scalable internal controls for complex transactions, strategic initiatives and evolving business processes. Evaluate control deficiencies, perform severity assessments, and drive timely remediation in partnership with control owners. Internal Control Transformation Drive opportunities for simplification, standardization and automation that strengthen the effectiveness, scalability, and future readiness of the control framework through innovation, aligned with argenx’s Vision2030 ambitions. Act as a trusted advisor to Finance and the broader organization on financial reporting risks, embedding effective internal controls into strategic initiatives and digital solutions. Audit Management Lead the coordination of SOX management testing with Internal Audit and act as the primary point of contact for External Audit, ensuring on‑time execution of the audit plans, timely fulfillment of audit requests, and effective cross‑functional collaboration. Control Awareness Build strong partnerships across Finance and the business to promote a culture of risk awareness, control ownership and accountability, supported by practical guidance and training. What Success Looks Like A scalable, future‑ready control framework that keeps pace with argenx's growth and is aligned with argenx’s Vision2030 ambitions. Reliable financial reporting supported by an effective and sustainable SOX environment. Control deficiencies identified early, assessed consistently, and remediated in a timely manner. Controls embedded into evolving business processes, strategic initiatives, and digital solutions. Strong stakeholder engagement, resulting in clear ownership and accountability for risks and controls. Efficient audit execution with high‑quality outcomes and constructive auditor relationships. SKILLS AND COMPETENCIES Essential Experience University degree in Finance, Business Administration, Accounting, or a related field (required). 6+ years of progressive experience in internal controls, external audit and/or internal audit. Proven experience in designing, implementing, and monitoring internal control frameworks within a US‑listed environment, partnering with local, regional and global teams to drive control effectiveness and SOX compliance. Demonstrated ability to coordinate SOX management testing with Internal Audit and effectively manage External Audit requirements and stakeholder engagement. Experience in biotechnology, pharmaceuticals or life sciences is a strong asset. Proficiency in English; additional languages are an advantage. Technical Strengths Ability to understand end‑to‑end business processes and associated risks and translate them into scalable and sustainable control solutions. Strong analytical and problem‑solving capabilities, using data‑driven insights to navigate complex business and control challenges while applying sound risk judgement. Experience evaluating control deficiencies and driving sustainable remediation. Ability to challenge the status quo and support transformative improvements across business processes through automation, simplification and scalable control design. Strong understanding of the Sarbanes‑Oxley Act (SOX), COSO principles, PCAOB auditing standards, and other regulatory compliance frameworks. Knowledge of IFRS and its application to financial reporting