Senior/Principal Scientist Biotransformations

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com (https://www.jnj.com.) .

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass cardiopulmonology, immunology, communicable diseases, neuroscience and oncology. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine, visit https:// https://www.jnj.com/innovative-medicine .

The Translational ADME Biotransformation team in Beerse, Belgium, is looking for a highly motivated Senior or Principal Scientist to support drug discovery and development programs. The team is part of the department of Translational Pharmacokinetics/Pharmacodynamics and Investigative Toxicology (TPPIT) and plays a pivotal role in support of drug metabolism related studies for small and large molecule drug discovery and development programs as well as in developing and applying advanced analytical chemistry solutions to solve mechanistic questions.

We are a highly motivated team, and our laboratories are state-of-the-art. As part of the global Translational ADME community within TPPIT, you will have access to a large arsenal of in silico, in vitro, in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.

Key Responsibilities

• To manage and coordinate metabolite profiling and identification studies for a broad range of modalities (small molecules, degraders, peptides, oligonucleotides, etc.), including design, plan and conduct of in vitro incubations, perform high quality analysis and write high quality scientific reports

• To perform liquid chromatography analysis with MS, UV and radioactive detection, including method development and data analysis and interpretation

• Serve as a subject matter expert for biotransformations, putting data into broader context and suggest and develop follow-up in vitro or in vivo experiments

• Effectively communicate data and their relevance to multidisciplinary project teams, management, and potential partners through internal and external presentations and publications

• To keep abreast with the current advances in MS, automation and related technologies and apply new technologies and methods to increase sensitivity, quality and throughput

Qualifications

• PhD in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics, Drug Metabolism or related field, or multiple years of relevant experience in the field of biotransformations

• Hands-on experience in structure elucidation using mass spectrometry

• In depth knowledge of biotransformation reactions and enzymes involved

• Hands-on experience with non-small modalities (oligonucleotides, peptides and proteins) is a