Principal Scientist Pharmacology

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacology

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

Position Title:

Principal Scientist Pharmacology.

3Rs Portfolio Innovation and External Engagement.

Location:

Beerse, Antwerp, Belgium

Role Summary

The Principal Scientist – NAMs Innovation is a scientific role within Scientific & In Vivo Strategies (SIS), responsible for executing/coordinating internal and external NAMs development/evaluation opportunities.

Working under the scientific direction of the Sr. Principal Scientist & SIS Scientific Lead, this role applies strong technical expertise in ex vivo , in vitro , and in chemico NAMs approaches that will enable identified NAM opportunities and support their appropriate development, evaluation and implementation to enable the portfolio, through a combination of both internal lab-based and externally managed efforts.

Operating within the enterprise 3Rs framework and aligned with Discovery, Product Development & Supply (DPDS), Preclinical Safety & Translational Sciences (PSTS), and SIS strategic priorities, the Principal Scientist plays a key role in translating NAM strategy into program‑relevant scientific insights, enabling strengthening of preclinical assessments and in silico approaches, improved clinical translational relevance, and enhanced alignment with 3Rs.

Primary Responsibilities:

Supporting Internal and External NAMs Development/Evaluation Efforts:

• Execute scientific evaluation of ex vivo , in vitro , and in chemico NAM opportunities relevant to discovery and development programs

• Support assessment of applicability, strengths, limitations, and readiness of NAMs within defined disease, modality, and context‑of‑use scenarios

• Partner with SIS Scientific Leads and TA/PSTS stakeholders to support evaluation and incorporation of NAMs into program and functional area strategies, under guidance of the Sr. Principal Scientist

• Enable in silico approaches through collaboration to understand and deliver on key outputs from ex vivo, in vitro and in chemico models to drive/improve upon in silico model development

External NAMs Landscape Monitoring:

• Track developments in the external NAMs landscape, including academic advances, emerging platforms, and biotech technologies

• Compile and synthesize information on scientific maturity, translational relevance, and regulatory context of external NAM approaches

• Provide structured summaries and analyses to support portfolio‑level discussions and prioritization

Internal Capability Execution:

• Support assessments of internal NAM capabilities and gaps relative to program needs and regulatory expectations

• Contribute to lab-based NAM development, evaluation, and validation activities, including documentation of learnings and outcomes

• Assist in development of internal tools, guidance, or exemplars that enable awareness and consistent application of NAMs across the enterprise

Scientific Collaboration & Communication:

• Act as a day‑to‑day scientific partner for TA and discovery area scientists seeking guidance on or collaboratively developing NAM‑enabled approaches

• Contribute to internal scientific r