Principal Scientist Nucleic Acid Sequencing Technologies

il y a 2 semaines

Bruxelles, Région de Bruxelles, Belgique GlaxoSmithKline Temps plein

Site Name: Belgium-Rixensart

Posted Date: Oct 23 2024

Are you looking for a role in Molecular Biology/Nucleic-Acid-based Technologies (NAT) that enhances your scientific expertise and allows you to develop innovative analytical methods thereby contributing to the production of best-in-class medicines, including mRNA-based vaccines? If so, this Principal Scientist role could be an ideal opportunity to explore.

Within the Analytical Development Department, the Molecular Analytics Platform is in charge of developing modern, state-of-the-art molecular methods to detect, quantify and characterize nucleic acids at all stages of vaccine development. The hired Associate Scientist will be in charge of executing, implementing, designing and developing methods for the detection, characterization and quantification of nucleic acids based on up-to-date nucleic acid technologies (NAT) and, in particular, methods aiming at sequencing mRNA vaccine-related products using Illumina and Oxford Nanopore technologies.

Your responsibilities:

  • Design and drive the development of next-generation sequencing analytical methods for next-generation mRNA vaccines using innovative NAT-based technologies and automation in collaboration with the other teams of the global analytical platforms.
  • Ensure the development, qualification, and validation of state-of-the-art analytical sequencing methods for mRNA identity, purity, integrity and content based on Illumina and Oxford Nanopore technologies.
  • Ensure implementation of QbD (Quality by Design) in the development of assays.
  • Work closely with the bioinformatics team to develop, adapt and validate bioinformatics workflows for mRNA identity, purity, integrity and content analyses.
  • Analyze mRNA sequencing data, generate actionable insights, and communicate findings in written and oral presentations to internal teams and external stakeholders.
  • Deliver quality data and sound science to drive decisions for new vaccine candidate projects, as part of end-to-end accelerated vaccine CMC development programs.

Scientific leadership:

  • Coach and mentor team members to promote and maintain excellence, and to create a high performing team delivering quality data to drive key decisions for the fast advancement of new mRNA technologies.
  • Provide guidance and mentorship to junior scientists, ensuring the team stays current with advances in sequencing technologies and bioinformatics tools.

Act as a key subject matter expert:

  • Think out-of-the-box, using sound science, paying attention to details to continuously improve and shape the CMC strategy & framework.
  • Act as a voice and ambassador of its department at various internal and external governance bodies and meetings.

Collaborate across teams:

  • Interact with Belgium- and US-based team members.
  • Interact and act in a complex matrix with several stakeholders from different departments (Research, Development, QC, RA, QA).
  • Interact with other GSK Vaccines Research and Development Centers (US and IT) and external partners.

Why you?

Basic Qualifications:

  • PhD in Molecular Biology, Biotechnology, Bioengineering or a related scientific field with an additional 3+ years of post-doc experience in the field.
  • Total education and experience of 8+ years in analytical sciences in the vaccine field.
  • Experience developing and implementing strategies with measurable outcomes.
  • Deep knowledge and routine use of at least one of the state-of-the-art Next Generation Sequencing technologies (Oxford Nanopore Technologies mandatory).
  • Proven expertise in bioinformatics pipeline developing, optimization and validation.
  • Fluency in English.
  • Good organizational skills.
  • Teamwork.

Preferred Qualifications:

  • A good understanding of biopharma / vaccine development process.
  • Good understanding of QbD principles.
  • Capacity to synthesize messages and ability to defend scientific and technical decisions to have constructive interactions and allow to take the right decisions.
  • Must have the ability to work with cross-functional teams.
  • Superlative presentation skills, across lines and levels and with senior stakeholders.
  • Problem-solving ability with limited information available to make decisions and interpretations.
  • Positive, open and can-do mindset.
  • Critical thinking ability is a must.
  • GMP basics is a plus.
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