Postdoc Unconventional T Cell Immunology

il y a 2 semaines


Gent, Flandre, Belgique Universiteit Gent Temps plein

Solliciteren tot :59 (Brussels time)
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Faculteit Geneeskunde en Gezondheidswetenschappen:

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Vakgroep: GE3
Diagnostische Wetenschappen
Tewerkstellingspercentage:100%

Aantal posities: 1

Type tewerkstelling:
Contract van bepaalde tijd**
Duur van de opdracht:2 years**
Geboden barema:PD1 tot PD4 (doctoraatdiploma)**
Diplomavoorwaarde:PhD**
About Ghent University
Ghent University is a world of its own.

Employing more than 15,000 people, it is actively involved in education and research, management and administration, as well as technical and social service provision on a daily basis.

It is one of the largest, most exciting employers in the area and offers great career opportunities.

With its 11 faculties and more than 80 departments offering state-of-the-art study programmes grounded in research in a wide range of academic fields, Ghent University is a logical choice for its staff and students.


The Bart Vandekerckhove lab
We discovered a novel CD8 T cell lineage in the human thymus. This lineage is characterized by the expression of CD8alphaalpha dimers, ZNF683, helios and KIRs. This lineage constitutes the third agonist selected TCRalphabeta lineage besides the CD161+ PLZF+ NKT and MAIT cells.

Unlike MAIT and NKT lineages, this lineage has a characteristic polyclonal T cell receptor repertoire enriched for hydrophobic and cysteine-cysteine interactions.

This lineage expands with increasing age, is associated with autoimmunity and is mainly found in the tissues. It is not known what these cells react to, nor whether these cells are regulatory or mainly effector cells.

See Verstichel G.et al Science Immunology 2017 and Billiet, L. et al. J Exp Med 2023 for further reading.

Assignment


Job opening concerns a postdoc position to study the role of the TCR in lineage commitment as well as the specificity of the TCR.

Experiments include in vitro differentiation experiments, humanized mice, single cell transcriptomics, TCR cloning and transduction.

Profile

  • You hold a PhD degree
  • Keen interest in T cell immunology
  • Strong expertise in molecular biology and bioinformatics
  • FELASA C to work with humanized mice
  • First author of one or more scientific publications

What we can offer you

  • A stimulation environment: you will join BVDK Lab situated in the Medical Research Building housing various research groups focusing on immunology.
  • A contract of 2 yrs. Your contract will start as soon as possible.
  • Your remuneration will be determined by salary scale PD1 to PD4 (if you hold a PhD). Click here for more information about our salary scales.
  • All Ghent University staff members enjoy a number of benefits, such as a wide range of training and education opportunities, 36 days of holiday leave (on an annual basis for a fulltime job) supplemented by annual fixed bridge days, a bicycle allowance and eco vouchers. Click here for a complete overview of all the staff benefits (in Dutch).

How to apply?
- your CV and an overview of your study results (merged into one pdf file)
- your motivation letter in pdf format
- a transcript of the required degree (if already in your possession). If you have a foreign diploma in a language other than our national languages (Dutch, French or German) or English, please add a translation in one of the mentioned languages.

  • Contact information of 2 references
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