Scientist in Structure, Spectro

Il y a 3 mois

Rixensart, Belgique GSK Temps plein

**Site Name**: Belgium-Rixensart
**Posted Date**: Oct 2 2024
- Spectrophotometric techniques as Fourier Transform infrared (FTIR), fluorescence (Fluo), Near and Far UV circular dichroism (CD) but also differential scanning calorimetry (DSC).
- Various colorimetric assays using UV spectrophotometry (proteins, mRNA, plasmid DNA, excipients, residual impurities), and
- More generic testing activities using Inductively Coupled Plasma (ICP), Atomic Absorption Spectroscopy (AAS), residual moisture content determination by coulometric Karl Fisher (KF) or Thermo Gravimetric Analysis (TGA), aluminum content by titration and other USP - EU Pharmacopeia tests

**Your responsibilities**:

- You plan & execute lab activities in collaboration with lab technicians and other scientists in the laboratories of the team located in Rixensart and Wavre sites.
- You provide support and technical advice to lab technicians.
- You participate in lab organization and maintenance, e.g. ordering reagents & consumables, follow-up of instruments maintenance & repair in collaboration with technicians, scientists & lab supports.
- You participate in method development according to Quality by Design (QbD) guidelines, in a phase-appropriate manner, and to provide fit-for-purpose analytical methods in interaction with Analytical Product Leaders & Sub teams (APL & AST), as well as Industrialization Leaders (AIL).
- You interpret and report results after an extensive check of the raw data quality and participate in the double-check of results generated by lab technicians and other scientists in the platform.
- You are deeply involved in generating appropriate analytical documentation, including qualification & validation protocols/reports.
- You present results in internal meetings (within the team, to ASTs, etc.).
- You may interact with other R&D departments (Preclinical, Drug Substance, Drug Product, Statisticians), as well as with GIO/QC organizations.
- You participate in scientific/technology watch in your domain of competency.

**_ Why you?_**

**Basic Qualifications**:

- We are looking for professionals with these required skills to achieve our goals:_
- Master’s degree in Chemistry, Biochemistry, Biophysics, Biology, Bioengineering, Chemical Engineering, Pharmacy, or other relevant discipline.
- Awareness of GMP environment/requirements, as well as of Quality by Design principles.
- The platform covers diverse analytical technologies:

- Fourier Transform infrared (FTIR),
- Fluorescence (Fluo),
- Near and Far UV circular dichroism (CD),
- Differential scanning calorimetry (DSC).
- UV spectrophotometry
- Inductively Coupled Plasma (ICP),
- Atomic Absorption Spectroscopy (AAS)
- Coulometric Karl Fisher (KF)
- Thermo Gravimetric Analysis (TGA)
- Titrations
- USP - EU - JP Pharmacopeia tests
- Expertise in some of these technologies is a must, as well as awareness for all of them.
- Ability to lead a method development project within the area of expertise.
- Sound scientific methodology and thinking, autonomy; commitment to solve problems and bring innovative solutions to the team.
- Communication skills (oral & writing), ability to engage the team; open-minded, result
- and quality-oriented.
- Fluent in French; English fluency is an asset.

**Preferred qualifications**:

- If you have the following characteristics it would be a plus_:

- Good knowledge of spectrophotometric principles, software, instrumentation, and potential impact on method development is a plus.
- Knowledge of method qualification/validation principles.
- Knowledge of SAP tool for processes such as results recording/validation, deviation & CAPA management.

Li-GSK

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.

**Why GSK?**

**Uniting science, technology and talent to get ahead of disease together.**

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their w

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