Phd with a Project Focused On Biomarker Discovery in Neurological Disorders

il y a 3 semaines


Antwerpen, Belgique Universiteit Antwerpen Temps plein

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Departement: Faculteit Farmaceutische, Biomedische en Diergeneeskundige Wetenschappen
Regime Voltijds

**Let’s shape the future - University of Antwerp**

The University of Antwerp is a dynamic, forward-thinking, European university. We offer an innovative academic education to more than 20000 students, conduct pioneering scientific research and play an important service-providing role in society. We are one of the largest, most international and most innovative employers in the region. With more than 6000 employees from 100 different countries, we are helping to build tomorrow's world every day. Through top scientific research, we push back boundaries and set a course for the future - a future that you can help to shape.

The Faculty of Pharmaceutical, Biomedical and Veterinary Sciences is looking for a full-time (100%) **PhD with a project focused on biomarker discovery in neurological disorders.**

**Position**

The Weckhuysen team and the Sleegers team at the VIB-UAntwerp Center for Molecular Neurology, Belgium are seeking a highly motivated PhD student as part of a joint project focused on biomarker discovery in neurological disorders. The Weckhuysen and Sleegers labs perform leading edge research discovering risk genes and analyzing molecular mechanisms in intractable epilepsy and in Alzheimer’s disease, respectively, using next-generation genetics technologies.

Early-onset epilepsy and Alzheimer’s disease (AD) are both frequent and debilitating conditions that profoundly impact patients’ lives. Early-onset epilepsy can be treatment resistant and is often accompanied by developmental and neuropsychiatric problems. AD leads to a progressive decline in memory, thinking and reasoning skills; it is the most common cause of dementia. For both epilepsy and AD, molecular diagnosis can be challenging due to the inaccessibility of the brain in most individuals. As such, there is an urgent need to identify reliable biomarkers from non-invasive sources to enable more accurate or earlier diagnosis.

This collaborative PhD project, co-hosted by the Weckhuysen and Sleegers labs, focuses on the discovery of biomarkers in epilepsy and AD using innovative laboratory and computational approaches. Samples from individuals with epilepsy, AD, and unaffected controls (including blood/serum, cerebrospinal fluid, and, where possible, brain tissue) will be analyzed. In this project, three complementary strategies will be explored. (1) We will analyze cell-free DNA (cfDNA) which is fragmented DNA released from dying cells. This cfDNA can contain mutations or chemical modifications (methylation) associated with specific disease mechanisms. (2) We will analyze extracellular RNA (exRNA), which provide an extra kinetic layer that can be indicative of a specific pathology. And (3), we will isolate and analyze extracellular vesicles (EVs), membranous particles secreted from cells that can contain protein, RNA, or DNA. The contents of these EVs can be investigated for cell-type specific biomarkers.

**Profile**
- Essential:_
- Master’s Degree in biochemistry, biomedical sciences, bioinformatics, (bio)statistics, bioengineering, computer science, related disciplines or equivalent through experience
- Proficient in verbal and written English.
- Ability to summarize data extracted from literature and to define research objectives.
- Passionate for science, critically-thinking, self-motivated, flexible, and enjoys working in a team
- Desirable but not required:_
- Hands-on laboratory experience with techniques such as next-generation sequencing, RT-qPCR, and nucleic acid extractions
- Programming experience, preferably in Python or R, and experience in the Linux environment
- Experience with large-scale data analysis, such as genomics or transcriptomics data
- Experience with a workflow management system such as Snakemake or Nextflow

**What we offer**

As part of the VIB-UAntwerp Center for Molecular Neurology and VIB, the applicant will benefit from established collaborations and access to centralized facilities with expertise in genomics, functional genomics and cell biology, proteomics, cutting-edge microscopy, structural biology, technology development, and bioinformatics.

The VIB-UAntwerp Center for Molecular Neurology has 7 PIs and hosts internationally recognized leaders in the field of Neurogenetics and Neuroinflammation. Current research groups address a broad set of questions related to neurodegenerative diseases of the central and peripheral nervous system, with an emphasis on understanding the genetic etiology and developing diagnostics and treatment methods for these diseases. Approaches range from human genetics, genomics, protein biochemistry and neuronal and glial cell biology to integrative sy



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