Postdoctoral Position to Study Tertiary Lymphoid Structures in Space and Time
il y a 5 jours
We have discovered that vascular/immunomodulating therapies can transform immunosuppressive tumor endothelial cells into immune-stimulating high-endothelial venules (HEV) that due to their specific functions, lead to substantial T and B cell infiltrates, reminiscent of tertiary-lymphoid structures (TLSs) (Allen E. et al Sci Transl Med 2017, Hua et al. Cancer Cell 2022; Guelfi et al. Nat Rev Cancer 2024). Congruently, HEV and TLS formation is associated with good prognosis and survival benefits in cancer while it worsens outcomes in chronic inflammation, supporting the notion that HEV/TLS structures are active centers of an immune response (Vella et al. Cancer Cell 2023). However, the underlying mechanisms of TLS formation, immune activity, and dependence on the vascular system remain largely unknown.
Can you use your strong expertise in immunology and/or vascular biology to unravel the vascular immune crosstalk for the generation and functional maturation of TLSs? Can you determine how the TLS vasculature forms immune cell niches that propagate TLS formation and maturation? Can you team up with us to therapeutically induce TLS in cancer to boost an immune response or abolish them in chronic inflammation/autoimmune diseases to cease the immune overreaction? If these projects interest you, you will enjoy working with a multidisciplinary team in a dynamic, stimulating working environment and close collaboration with clinical and industrial partners.
**How to apply?**:
If you want to make the journey with us to decipher TLS regulation and function, then we would like to hear from you.
- A detailed CV, including a list of your scientific publications and achievements
- A detailed cover letter describing your motivation
- The contact information of 3 referees
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