Scientist Global Translation Dmpk Sciences

il y a 1 jour

Beerse, Belgique Johnson & Johnson Temps plein

Janssen Pharmaceuticals is recruiting for a **Scientist position in Global Translational DMPK Sciences **, located in Beerse.

**Key Responsibilities**:
The research scientist within the TPPIT department will take a leading role in designing, conducting, and interpreting translational DMPK studies, all sought at improving our success in bringing differentiated medicines to patients. The key responsibilities of this position will be the following:

- Providing project teams with mechanistic understanding and data integration of the correlation between in vitro and in vivo absorption, distribution, metabolism, excretion (ADME) properties, drug-drug interaction liabilities for enzymes and drug transporters, and the relationship between PK/toxicokinetics and PD response.
- Identifying, evaluating, and implementing novel assays and next generation in vitro models to support the ADME characterization of small molecules and other modalities like oligonucleotides, peptides, antibody-drug conjugates, and others.
- Designing, planning, and conducting hypothesis driven translational research; providing interpretation of data and communicating/reporting results and recommendations to project teams.
- (Co)-authoring/reviewing study reports of DMPK data in preparation for internal governance bodies as well as regulatory agencies.
- Working collaboratively and cross-disciplinary to tackle scientific problems

**Qualifications**:
**Education and Experience Requirements**:
**Required**:

- PhD in Pharmaceutical Sciences, Biology, Pharmacology, Biomedical Sciences or equivalent.
- (Hands-on) experience with in vitro liver (e.g. hepatocytes, next generation 2D and 3D fluidics models) and/or gastrointestinal (e.g. intestinal organoids, 3D microtissues, others) and/or other tissue models of relevance (e.g. kidney, brain).
- (Hands-on) experience in in vitro enzymology, drug transporters, drug metabolism, disposition and/or toxicity studies are desired.
- Ability to independently diagnose and design specific tailor-made study packages to address complex compound-specific problems.
- Strong Scientific interest with confirmed capability to perform independent research indicated by a proven scientific track record.
- English, professional level

**Preferred**:

- Prior postdoctoral experience (1 - 3 years) in a relevant field is a plus.
- Interest/knowledge in PK and bioanalytical assay development (eg LC/MS) are a plus.
- Great teammate with strong interpersonal skills, scientific curiosity, creativity and a strong sense of responsibility and accountability.

**Benefits**:
We offer a competitive salary and extensive benefits package. The health and well-being of our employees is a priority, we have a flexible working environment as we value work-life balance. We offer career development opportunities for those who want to grow and be part of our organization. We are Janssen

Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will be considered for employment without regard to any other characteristic protected by law.

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