Sr. Scientist Psts Transl. Pk
il y a 1 jour
**Job Function**:
Discovery & Pre-Clinical/Clinical Development
**Job Sub Function**:
Pharmacokinetics & Pharmacometrics
**Job Category**:
Scientific/Technology
**All Job Posting Locations**:
Beerse, Antwerp, Belgium
We are a highly motivated team, and our laboratories are state-of-the-art. As part of the global Translational ADME community within TPPIT, you will have access to a large arsenal of in silico, in vitro, in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.
**Key Responsibilities**
- Lead the design and execution of advanced analytical chemistry experiments, primarily involving mass spectrometry, interpret the data and write high-quality reports, all aimed at improving our success in bringing differentiated medicines to patients.
- To perform biological imaging using MALDI or DESI in combination with high resolution or triple quadrupole mass spectrometry, including room temperature and cryogenic sample preparation methods.
- To perform laser microdissections to pinpoint and isolate distinct subcellular components for detailed molecular assessment. Use advanced 2D-liquid chromatography - mass spectrometry setups to enable the qualitative and quantitative measurements of low analyte concentrations in these sections.
- Maximize the output from raw data using appropriate software and statistical analysis tools.
- Collaborate within multidisciplinary teams to contextualize data within broader research objectives, propose and develop follow-up experiments, and document and present findings.
- Stay updated on advancements in mass spectrometry and related technologies. Implement new technologies and methods to enhance sensitivity, quality and throughput for accelerating research and improving scientific data quality.
**Qualifications**
- PhD in Analytical or Medicinal Chemistry, Pharmaceutical Sciences, Biochemistry, or related field or a master’s degree in chemistry, biochemistry, or related field with 10 years of relevant experience
- 5 years hands-on experience with high-resolution mass spectrometry for imaging, quantification or structure elucidation
- Advanced hands-on experience in small molecule, oligonucleotide analysis, protein analysis, 2D-chromatography, in a Pharma R&D environment or as a post-doc are assets
- Knowledge of biotransformation reactions and enzymes involved are assets
- Proficiency in data analysis software and ability to interpret complex datasets
- Strong problem-solving skills with the capacity to independently diagnose and tackle complex technical and scientific problems
- Strong track record of scientific contributions including peer reviewed publications, patents, or presentations at major meetings is considered a plus
- High level of flexibility, creativity and sense of responsibility
- Team player with strong interpersonal skills in an international team setting
- Strong communication skills in English, both written and verbal
**What We Offer**:
- Competitive salary and benefits package
- Opportunities for professional development and career advancement
- Collaborative and inclusive work environment
- Access to state-of-the-art technology and resources
**If you are passionate about mass spectrometry and want to be part of a team dedicated to scientific excellence, please submit your resume and a cover letter via our career site.
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