Safety Pharmacology in Vivo Technician

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

**Job Summary**:
The primary responsibility of the in vivo technician is to provide research support for the Safety Pharmacology team in Janssen R&D Beerse, in particular to the integrated behavioral, EEG and cardiovascular assessment in rats. The technician is expected to strive for excellence in all aspects of the profession of laboratory animal science and maintain the highest standard of personal conduct. The technician is stakeholder-focused, strong at collaborating with internal and external partners and delivers results through both individual contributions and teamwork. The technician will ensure compliance with all applicable animal welfare regulations and guidelines, the Guide for the Use and Care of Laboratory Animals and internal compliance standards.

ESSENTIAL RESPOSNABILITIS
- Provide quality animal care to animals, including providing food and water, cleaning animal cages and rooms and provides support with enrichment and socialization activities
- Execute safety pharmacology in vivo studies to assess the tolerability and efficacy of novel test articles
- Organization of internal studies, including preparation and identification of study animals, preparation of test articles) for administration, use automated data collection systems for analysis and interpretation
- Perform standard rodent procedures including dosing and blood collection via multiple routes. Deliver rodent anesthesia and monitoring
- Perform routine observations and submit health concerns
- Collect tissue for necropsy for downstream processing following euthanasia
- Work independently and as a team member to conduct in vivo laboratory studies
- Understand the 3Rs and follow ethical protocol and amendments; perform in vivo studies to ethical guidelines and policies.
- Create study reports, assist with preparing regulatory submission documents
- Implement and maintain good documentation practices
- Stay current with the literature and technological advances in relevant fields
- Perform all other related duties as assigned

**Educational Requirements**:
B.S. or M.S. in a biological science with hands-on in vivo experience
Solid background in cardiovascular pharmacology, with knowledge or experience in safety pharmacology core battery a plus
Telemetry experience and/or experience with Ponemah or EMKA software and/or experience in small-animal surgery with anesthesia and wound closure using aseptic techniques would be at a distinct advantage
Proficiency in handling instrumented and anesthetized rodents, as well as laboratory techniques: PO, IP, SQ, IM, IV injection dosing; blood collection via tail and/or submandibular vein, vena cava, retroorbital venous plexus, cardiac puncture
Executing detailed in vivo work plans/experimental protocols through strong organizational skills and attention to detail
Familiarity with entering data, analysis, and interpretation into appropriate notebooks and/or databases

**About Insourcing Solutions**
Charles River Insourcing Solutions℠ can streamline research by delivering operational and cost efficiencies through the strategic insourcing of GMP, GLP and non-GLP research services from discovery through safety assessment. Insourcing Solutions℠ provides you with the ability to maintain control of your facility and expertise while leveraging available space.