Digital Twin Implementation for Viral Vector

il y a 1 semaine

Mons, Wallonie, Belgique Systems, Estimation, Control and Optimisation (SECO) Group from the University of Mons (Belgium) Temps plein

DIGITAL TWIN IMPLEMENTATION FOR VIRAL VECTOR PRODUCTION PROCESS:

  • Réf
    ABG-123414
  • Sujet de Thèse 25/04/2024
  • Financement public/privé
  • Systems, Estimation, Control and Optimisation (SECO) Group from the University of Mons (Belgium)
  • Lieu de travail
  • Mons (UMons)
  • Belgique
  • Intitulé du sujet
  • DIGITAL TWIN IMPLEMENTATION FOR VIRAL VECTOR PRODUCTION PROCESS
  • Champs scientifiques
  • Sciences de l'ingénieur
  • Génie des procédés
  • Robotique


 Mots clés
  • Mathematical modeling, machine learning, optimisation, control systems, bioprocess, identifiability
    Description du sujet:
  • The biopharmaceutical industry, including gene therapy, represents a significant percentage of Belgian economical activities. Bioprocessing based on digital twins and process analytical technologies are key areas of innovation for the pharmaceutical industry, and the present project will use digital twin implementation for streamlining and up-scaling the viral vector production process (see below).
  • This research project, offering a 4-year PhD fellowship, will be developed at the UMONS
  • CER in collaboration with a consortium of Belgian Universities and aims to model the viral vector production process, including parameter estimation, process optimization, hybrid modeling and machine learning. The applicant profile should therefore be of a control engineer, electrical engineer, chemical or biochemical engineer, preferentially with a background in systems, mathematical modeling and machine learning.
This applied research project targets modeling of bioprocesses in a broad sense, focusing on:

  • Datadriven modeling techniques
  • System identifiability
  • Hybrid modeling
  • Physicsinformed machine learning


The research will be achieved in the SECO (Systemes, Estimation, Control and Optimization) Lab of the University of Mons (Mons, Belgium) but also in possible partnership with another european research group (with possible long stays abroad).


Prise de fonction:

  • 01/09/2024
    Nature du financement:
  • Financement public/privé

Précisions sur le financement:

  • Win4Excellence Program of the Walloon Region
    Présentation établissement et labo d'accueil:
  • Systems, Estimation, Control and Optimisation (SECO) Group from the University of Mons (Belgium)
Founded in 1837, the Faculty of Engineering of Mons (FPMs) is the oldest Engineering Faculty in Belgium, with 25 research and education departments, approximately 1000 students, and a large panel of bilateral, Erasmus-Socrates and TIME agreements. Since 2010, FPMs is now the Faculty of Engineering of the University of Mons (UMONS).
The SECO Department of the Engineering Faculty of UMONS has a staff of about 20 collaborators.
It ensures undergraduate and graduate education in automatic control. Research has developed in several directions of mathematical modeling, parameter and state estimation, and process control. The group participates actively in two research institutes of UMONS, namely Energy and Biosciences.
SECO has established collaborations with academic and industrial institutions in different parts of the world.

Site web:

Intitulé du doctorat:

  • PhD in Engineering Science and Technology
    Pays d'obtention du doctorat:
  • Belgique

Etablissement délivrant le doctorat:

  • University of Mons
    Ecole doctorale:
  • Graduate School in Systems, Optimization, Control and Networks (SOCN)
    Required skills:
  • Engineering education (control, data science or biochemical engineering)
  • Good programming skills (Matlab/Python/Julia)
  • Mathematical modeling and parameter estimation
  • Numerical simulation and optimization
  • Metabolism and kinetics
-
Soft skills:

  • Team spirit
  • Flexibility
  • Open to acquire new and/or transversal knowledge
  • Good organization and work autonomy
-
Languages:

  • Fluent in English
  • Basics in French (or willing to learn through offered French courses) 31/05/2024

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