Phd Position in Molecular and Computational
Il y a 2 mois
**Project description**:
We are a highly motivated international team of researchers at the Molecular Neurogenomics group (Jordanova Lab) and the Computational Neurobiology group (Malysheva Lab) at the VIB CMN. We are excited to announce a call for a joint PhD student in our labs to work on a challenging project at the interface of neurodegeneration, genomics, computational and systems biology.
Charcot-Marie-Tooth disease (CMT) represents the most common genetic disorder of the peripheral nervous system. Patients experience progressive distal muscle weakness and wasting, sensory loss, and skeletal deformities ultimately leaving them severely disabled. This lifelong disorder is currently incurable. The largest protein family implicated in the etiology of CMT are aminoacyl-tRNA synthetases (ARS). Ubiquitous and essential enzymes, ARS catalyse a critical step in protein biosynthesis by charging tRNA with their cognate amino acid. Jordanova Lab reported that dominant mutations in the tyrosyl-tRNA synthetase (YARS) cause a clinical variant of CMT and so far six additional cytoplasmic ARS have been implicated in the same pathology.
The overarching goal of this proposal is to understand why and how dysregulation of omnipresent and constantly expressed ARS proteins leads to dying-back neurodegeneration and affects specifically the peripheral neurons (PNs). This neuronal population contains the most polarized cells in our body and their sophisticated morphology and function render them highly susceptible to degeneration. The preliminary data generated in-house as well as the available public data suggest mechanisms involving genetic, epigenetic and chromatin organisation factors governing the cell-type specific response to ARS mutations. Therefore, an integrative genome-wide cis-regulatory network analysis approaches, developed and employed in the Malysheva Lab, are required to reveal these mechanisms.
With the proposed project we aim to bridge this gap in our knowledge of cis-regulatory mechanisms underlying this disease and reveal the mechanisms underlying the strong cell-type specific effect of the CMT-causing YARS mutations. For this we will generate high-resolution spatial chromatin organisation, chromatin accessibility and gene expression data for all major cell types forming the peripheral nerve environment (as well as controls), generated from the patient-derived iPSCs and integrate these data into the cis-regulatory networks. Following cis-GRN network reconstruction and formal graph analysis, we will identified key regulatory factors governing cell-type specific reponse to CMT-causing mutations. Finally, we will validate the identified key (epi)genetic molecular and eplore their therapeutic potential in _in vitro_ and _in vivo _disease models_._
**Profile**:
- have an MSc in Systems Biology, Molecular Biology, Natural Sciences or related disciplines
- be very motivated and enthusiastic to learn and expand both computational and experimental skill sets
- have an analytical mindset
- be able to summarize data extracted from the literature and clearly shape research objectives
- be able to efficiently communicate with experimental and computational scientists
- have excellent communication and writing skills in English
**Required skills**
- confident in basic molecular biology techniques, such as cell cultures, basic genomics data generation
- knowledge of (theory behind) gene regulatory mechanisms and multimodal data integration
- basic/intermediate programming skills in R and/or Python
- Ability to adapt to the research environments while being full members of two labs
**Desirable skills**
- statistical analysis
- basic processing of NGS data
- experience with iPSC and/or cell culturing
- knowledge of and some experience with genetic perturbation assays, such as CRISPR
**We offer**:
As part of the VIB-UAntwerp Center for Molecular Neurology and VIB, the applicant will benefit from established collaborations and access to centralized facilities with expertise in genomics, functional genomics and cell biology, proteomics, cutting-edge microscopy, structural biology, technology development, and bioinformatics.
VIB provides a highly interactive environment and ample training opportunities for its researchers. In addition, the VIB-UAntwerp Center for Molecular Neurology is located in the city of Antwerp, the capital of Flanders, offering a culturally and historically rich, and ethnically diverse environment.
The VIB-UAntwerp Center for Molecular Neurology has 7 PIs and hosts internationally recognized leaders in the field of Neurogenetics and Neuroinflammation. Current research groups address a broad set of questions related to neurodegenerative diseases of the central and peripheral nervous system, with an emphasis on understanding the genetic etiology and developing diagnostics and treatment methods for these diseases. Approaches range from human genetics, genomics, protein biochemistry and neuronal a
-
Phd Position in Molecular and Computational
Il y a 5 mois
Antwerpen, Belgique VIB-UAntwerp Center for Molecular Neurology Temps plein**Project description**: We are a highly motivated international team of researchers at the Molecular Neurogenomics group (Jordanova Lab) and the Computational Neurobiology group (Malysheva Lab) at the VIB CMN. We are excited to announce a call for a joint Ph.D. student in our labs to work on a challenging project at the interface of neurodegeneration,...
-
Phd Molecular and Computational Neurogenomics
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Faculteit Farmaceutische, Biomedische en Diergeneeskundige Wetenschappen Regime Voltijds **Let’s shape the future -...
-
Postdoctoral Position in The Lab of Computational
il y a 2 semaines
Antwerpen, Belgique VIB Temps plein**Project description**: The Computational Neurobiology lab studies causal mechanisms underlying normal and aberrant cellular decision-making in the human brain in health and neurodegenerative diseases. We investigate the role of spatial chromatin organization in cell fate acquisition and maintenance, using a variety of targeted and genome-wide profiling...
-
Doctoral Scholarship Holder in The Field of
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Centrum voor Moleculaire Neurologie Regime Voltijds **Let’s shape the future - University of Antwerp** The...
-
Senior Researcher or Postdoc in The Lab of
il y a 2 jours
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. **Van vrijdag 15 november, 17u tot en met maandag 18 november 2024 is het niet mogelijk om online te solliciteren of je...
-
Phd Position Quantitative in Situ Electron
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Departement Fysica Regime Voltijds **Let’s shape the future - University of Antwerp** The University of Antwerp is...
-
Phd Positions Quantitative in Situ Electron
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Departement Fysica Regime Voltijds **Let’s shape the future - University of Antwerp** The University of Antwerp is...
-
Professor Experimental Parasitology
Il y a 5 mois
Antwerpen, Belgique Instituut voor Tropische Geneeskunde Temps plein**Introduction**: The Institute of Tropical Medicine (ITM) in Antwerp, Belgium, aims at the advancement and spread of science that contributes to infectious diseases understanding, medicine and public health, with a global focus on low and middle income countries.. ITM conducts scientific research, delivers advanced education and provides medical, scientific...
-
Principal Scientist Drug Chemistry
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson**: The Center of Excellence for Predictive Analytics and Stability Sciences (CoE PASS) operates within the Global Analytical Development Synthetics organization, a division of the Therapeutics Development & Supply (TDS) department at Johnson & Johnson Innovative Medicine. In CoE PASS, we foster a dynamic team, uniting...
-
Lab Technician
il y a 4 semaines
Antwerpen, Belgique VIB Temps plein**Description**: The laboratory of Neuroimmunology (NIM), headed by Prof. Dr. Emanuela Pasciuto, is a part of the VIB-Center for Molecular Neurology (CMN) and focuses on multiple aspects of T cells biology in the context of neuropathology. We are looking for a lab technician who will join the team and provide hands-on support in tasks related to mouse...
-
Postdoctoral Researcher Radiopharmacy/radiochemistry
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Moleculair -Morfologie-Microscopie Regime Voltijds **Let’s shape the future - University of Antwerp** The...
-
Lab Technician
Il y a 2 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Centrum voor Moleculaire Neurologie Regime Voltijds **Let’s shape the future - University of Antwerp** The...
-
Bell Labs Internship
Il y a 5 mois
Antwerpen, Belgique NOKIA Temps plein**Come create the technology that helps the world act together** Nokia is committed to innovation and technology leadership across mobile, fixed and cloud networks. Your career here will have a positive impact on people’s lives and will help us build the capabilities needed for a more productive, sustainable, and inclusive world. We challenge ourselves...
-
Lab Technician
il y a 4 jours
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Centrum voor Moleculaire Neurologie Regime Voltijds **Let’s shape the future - University of Antwerp** The...
-
Laboratory Technician
il y a 4 jours
Antwerpen, Belgique VIB Temps pleinThe Laboratory for Gut-Immune-Brain Axis Research is a newly established and expanding research group led by Dr. Sebastiaan De Schepper. The lab focuses on how the peripheral immune system shapes the brain immune landscape in health and disease, with a particular emphasis on tissue-resident macrophages along the gut-brain axis. We use various transgenic...
-
(Senior) Associate Scientist Discovery and
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson** At Johnson & Johnson Innovative Medicine, Communicable Disease unit our goal is to build new innovative products addressing key public health challenges and this includes building robust external engagements with key public and private institutions across the world. Communicable Disease unit is committed to developing novel...
-
(Senior) Solid State Scientist in Pharmaceutical
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson**: Pharmaceutical & Material Sciences is, within the Pharmaceutical Development & Supply (PPDS) organization of the Pharmaceutical Companies of Johnson and Johnson, responsible for preformulation & biopharmaceutics, solid state form selection, material selection and qualification. In Belgium (Beerse) there is a vacancy for a...
-
Doctoral Scholarship Holder to Study The Epigenetic
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Moleculaire Beeldvorming, Pathologie, Radiotherapie, Oncologie Regime Voltijds **Let’s shape the future -...
-
Post-doc Biocatalysis
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**Post-Doc Biocatalysis** **Company Profile** Caring for the world, one person at a time, inspires and unites the people of Johnson & Johnson. We embrace innovation—bringing ideas, products, and services to life to advance the health and well-being of people around the world. We believe in collaboration which has led to breakthrough after breakthrough,...
-
Postdoc Scientist
Il y a 3 mois
Antwerpen, Belgique Johnson & Johnson Temps pleinJoin Johnson & Johnson Innovative Medicine as a Postdoc in our Discovery Omics team in Beerse, Belgium. This is a fixed term contract. This exciting opportunity involves working on an innovative project funded by the Flemish Government, where you'll help create an innovative high throughput single cell transcriptomics solution. Your work will have a profound...
