Senior Researcher or Postdoc in The Lab of
il y a 1 mois
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**Van vrijdag 15 november, 17u tot en met maandag 18 november 2024 is het niet mogelijk om online te solliciteren of je sollicitatie te vervolledigen, aangezien er een onderhoud plaatsvindt aan het systeem.**
Departement: Centrum voor Moleculaire Neurologie
Regime Voltijds
**Let’s shape the future - University of Antwerp**
The University of Antwerp is a dynamic, forward-thinking, European university. We offer an innovative academic education to more than 20000 students, conduct pioneering scientific research and play an important service-providing role in society. We are one of the largest, most international and most innovative employers in the region. With more than 6000 employees from 100 different countries, we are helping to build tomorrow's world every day. Through top scientific research, we push back boundaries and set a course for the future - a future that you can help to shape.
The VIB Center for Molecular Neurology at The University of Antwerp is looking for a **full-time (100%) senior researcher/**postdoc** **in the lab of computational neurobiology**
**Position**
In the Computational Neurobiology lab, we study causal mechanisms underlying normal and aberrant cellular decision-making in the human brain in health and neurodegenerative diseases. We investigate the role of spatial chromatin organization in cell fate acquisition and maintenance, using a variety of targeted and genome-wide profiling technologies and develop statistical and machine learning approaches for multimodal data integration and cis-regulatory network reconstruction.
We are looking for a talented and highly motivated scientist for a postdoctoral position in our lab to work on a project at the intersection genetics, systems biology and computational biology to study the regulatory mechanisms underlying cell-type specific switching of alternative gene isoform in different types of dementia, generously supported by the Alzheimer’s Association.
The human brain shows some of the widest isoform diversity of any organ and has therefore been an important model for studying alternative splicing. Intriguingly, recent studies showed widespread changes in isoform usage, specifically in usage of alternative transcription start site (ATSS) and alternative transcription termination site (ATTS) of causal disease genes, in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). These observations to the forefront the significance of ATTS/ATTS choice across neurodegenerative diseases and the need for comprehensive holistic research into the mechanisms regulating it, as currently the knowledge of these mechanisms is severely lacking. Most recently, large-scale changes in 3D chromatin organization and epigenetic factors have been shown to affect or correlate with alternative splicing/exon usage. Yet, there has never been a systematic study of the precise mechanisms governing ATSS/ATTS choice, on a genome-wide scale at high-resolution, nor of the role of the combined action of chromatin organization and epigenetic factors in these mechanisms. The proposed project is aiming to bridge this gap, (i) build isoform-specific regulatory atlas for the human brain in health and disease, (ii) identify causal regulatory elements and transcription factors responsible for determining ATSS and ATTS choice in disease and (ii) identify putative causal disease isoforms with a genetic underpinning in dementia.
**Profile**
- You hold a PhD in biomedical sciences, molecular biology, cellular biology, systems biology or related disciplines
- possess advanced molecular and cellular biology skills, including approaches for generation of omics data, FACS/FANS and CRISPR-mediated perturbation approaches
- have solid knowledge of and experience in single-cell data analysis and multimodal data integration
- have strong knowledge of gene regulatory mechanisms
- have basic/intermediate programming skills in R and/or Python
- have excellent communication and writing skills in English
- have strong academic record
**What we offer**
- Financial support for one year with a formal evaluation at the end of that year. Since we are aiming for a long term collaboration, there will be the opportunity to extend the contract following a positive evaluation.
- Access to state-of-the-art infrastructure and core experimental and computational facilities in a vibrant, worldclass research environment operating at an international level
- Dedicated training programs available through VIB and UAntwerp to broaden your expertise and enhance your skill set
- A stimulating international research environment
- A strong and dynamic network of international collaborators
- The planned start date is February 2025 or as soon as
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