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Formulation Scientist
il y a 3 jours
**About Johnson & Johnson**:
J&J Innovative Medicine Research & Development develops treatments that improve the health and lifestyles of people worldwide. R&D development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, diabetes, hematology, metabolic disorders, immunologic disorders, pulmonary hypertension and reproductive medicine. Within Pharmaceutical Product Development & Supply (PPDS), we are recruiting a **Formulation Scientist - Novel Oral Modalities **in the **Parenterals & Liquids Development **(PLD) department in Beerse, Belgium.
In the PLD team, we are at the forefront of innovation. We develop groundbreaking Parenteral and Liquid drug product formulations and processes across our R&D Synthetics portfolio (small molecules, peptides, oligonucleotides), from late Discovery to Commercialization. This portfolio covers a variety of formulation types such as solutions, (nano)suspensions, liposomes, lipid-based systems, biodegradable microspheres and rods for various administration routes. This position focuses on establishing new formulation approaches for oral delivery of macromolecules and non-conventional small molecules (Novel Modalities).
As a Formulation Scientist within this role, you will build liquid drug delivery technologies and processes for peptides and poorly absorbed macromolecules and contribute to scientific and technical advancements in this constantly evolving field. You will lead and implement Innovation and Development activities by providing experimental and intellectual input regarding formulation design and manufacturing process development for this new modality. You will collaborate and coordinate with authorities across different areas of drug discovery and pharmaceutical development (pharmaceutical and materials sciences, biopharmaceutics, analytical development, DMPK, IP,) and you will develop formulations for preclinical studies and clinical trials. This position will include hands-on, lab-based research while offering leadership and growth opportunities. We are seeking an individual who is passionate about the prospect of assimilating new insights and transform challenges into innovative ideas and practical solutions.
**Key Responsibilities**:
- Performs formulation and process development activities for innovative parenteral and liquid dosage forms across our R&D Synthetics portfolio, with strong focus on delivery and oral absorption enhancement of peptides and other beyond Rule of 5 molecules.
- Designs formulations, performs hands-on laboratory work and collects results in electronic lab notebook and reports. Development activities span from discovery over preclinical to clinical phases.
- Develops expertise in assigned technical areas, searches the academic and patent literature to identify current practices, gaps and opportunities relating to the scientific field, and translates new insights into patient-centric solutions in support of drug development.
- Collaborates with various internal partners in Drug Development such as Pharmaceutical & Material Sciences, Analytical Development, Discovery Pharmaceutics, Preclinical Safety & Translational Sciences and Pharmaceutical Supply & Engineering Sciences and collaborates with external academic partners and CDMOs.
**Qualifications**:
**Education**:
- Ph.D. degree (minimum of 4 years of relevant experience) or Master’s degree (minimum of 7 years of relevant experience) in Pharmaceutical Sciences / Chemistry / Bio-engineering / Chemical Engineering.
**Experience and Skills**:
**Required**:
- Demonstrated expertise in drug delivery of oral peptides and beyond Rule of 5 molecules.
- Experience in lipid-based formulation design and process development (liposomes, solid-lipid nanoparticles, SNEDDS) for various routes of administration and good understanding of gastro-intestinal permeation/absorption enhancement as well as physical pharmacy and biopharmaceutical principles.
- Ability to leverage literature, evaluate and screen new dosage forms, manufacturing technologies and new drug delivery opportunities.
- Scientific curiosity, innovation mentality, critical thinking capabilities and problem-solving attitude.
- Excellent teammate with strong oral and written communication skills, who thrives in a collaborative environment. Ability to partner with external (academic) networks and CDMOs.
- Ability to quickly adapt to constantly evolving scientific challenges with a sense of accountability, leadership and achievement.
- Ability to conduct hands-on experiments accurately and safely in a modern laboratory environment.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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