Postdoctoral Scientist Biopharmaceutics
Il y a 2 mois
Postdoctoral Scientist Biopharmaceutics - (PBPK modeling of Amorphous Solid Dispersions)
Location: Beerse, Belgium
The J&J IM Discovery, Product Development, & Supply (DPDS) organization helps early career scientists gain the training and experience needed to further develop their careers while addressing the needs of global healthcare. Postdocs work side-by-side with DPDS scientists on innovative research projects. They learn the functional role of scientists in the pharmaceutical industry and receive valuable career advice from mentors while building a network of professional contacts and developing the skills needed to advance their careers.
We are seeking a talented Postdoctoral scientist to join our Pharmaceutical and Material Sciences (PMS) team, which is part of the global Pharmaceutical Product Development & Supply (PPDS) organization within J&J IM R&D to be based in Beerse, Antwerp, Belgium. The PMS team is responsible for pre-formulation and biopharmaceutics, solid state form selection and understanding, and material selection and qualification to provide end-to-end support to the J&J IM synthetic modality portfolio.
The main objective of this 18-months Postdoc project is to develop novel PBPK capabilities that integrate the key insights gained from in vitro and preclinical experiments within the currently available PBPK frameworks to allow better predictions of the plasma concentration time profile of drugs formulated as amorphous solid dispersions. The project is partially funded by Flanders innovation & entrepreneurship (VLAIO).
Efforts in this project will mainly focus on mathematical modeling of key in vitro biopharmaceutics experiments such as drug solubility, dissolution, and others to confirm/estimate key input parameters such as amorphous solubility (aqueous and in presence of bile micelles), ionization constants, solubility factors, precipitation rate etc. prior to using them within PBPK Models. Novel PBPK methodologies will be developed that leverage our improved understanding of ASD release mechanisms (congruent or incongruent) and the formation of drug-rich nanodroplets (liquid-liquid phase separation) and their particle size distribution towards intestinal drug permeation.
As a Postdoctoral scientist, you will operate under limited supervision with a high level of autonomy to transform drug delivery challenges into innovative ideas and practical solutions consistent with project objectives. On the job training will be provided by qualified staff. Additionally, you might be authoring scientific publications and present data to the scientific community internally and externally. This position may require limited lab work and will be mainly focused on PBPK modeling, while offering ample scientific leadership and personal growth opportunities through training, mentoring and R&D-wide connectivity.
Position Responsibilities
Interpretation of in vitro biopharmaceutical data on amorphous solid dispersions, including solubility, biorelevant dissolution, permeability, solid state characteristics, dynamic light scattering, and others.
Literature Review
Incorporation of in vitro data into existing PBBM/PBPK software and development of novel PBBM/PBPK methodologies.
Authorship and publication of scientific reports
Development, training, conferences, internal meetings & symposia
**Qualifications**:
A PhD degree in Pharmaceutical Sciences, Chemical engineering, Pharmaceutical Technology, Analytical Sciences, or closely related field with relevant experience in biopharmaceutics.
Demonstrated competency and experience in biopharmaceutics, formulation development and/or characterization. Experience in PBPK modeling is highly preferred.
Experience with biopharmaceutical in vitro techniques (e.g. solubility, dissolution, precipitation, solid state characterization, permeability ).
Experience in coding, e.g. R, Python, Matlab,
Proven ability to transform drug delivery challenges into innovative ideas and practical solutions.
To make your ideas practical, you must possess a good amount of innovation and creativity and be able to think and act unconventionally.
Organizational, planning, problem-solving and scientific/technical leadership skills needed in the completion of the postdoc project deliverables.
Track record of scientific contributions, including peer reviewed publications and presentations, and/or patents.
Excellent oral and written communication skills and efficient information exchange in English.
On-site presence (Beerse, Antwerp area, Belgium).
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.
We know that the success of our bus
-
Postdoctoral Fellow
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps pleinThe J&J IM Discovery, Product Development, & Supply (DPDS) Postdoctoral Fellowship Program helps early career scientists gain the training and experience needed to further their careers while addressing the needs of global healthcare. Postdocs work side-by-side with DPDS scientists on innovative research projects and have the opportunity to present and...
-
Postdoctoral Scientist
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps pleinJohnson & Johnson is currently seeking a Postdoctoral Scientist in the Oncology field to join located in Beerse (temp contract of 3 years). **Primary responsibilities (include, but are not limited to)**: - Demonstrate the ability to design, perform, interpret, troubleshoot and report complex data. - Ability to perform tissue culture is a must....
-
Principal Scientist Drug Chemistry
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson**: The Center of Excellence for Predictive Analytics and Stability Sciences (CoE PASS) operates within the Global Analytical Development Synthetics organization, a division of the Therapeutics Development & Supply (TDS) department at Johnson & Johnson Innovative Medicine. In CoE PASS, we foster a dynamic team, uniting...
-
Postdoctoral Fellow
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**Postdoctoral Fellow - Deep Learning / Machine Learning** The position can be based in Beerse, Belgium. Remote work options may be considered on a case-by-case basis and if approved by the company. **Role and responsibilities - Research and develop deep learning methods to effectively train graph neural networks for Quantum Mechanics and other physics...
-
(Senior) Associate Scientist Solid Formulation of
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson** Global Chemical and Pharmaceutical Development & Supply (CPDS) is within the Discovery, Product Development & Supply (DPDS) organization of Pharmaceutical Companies of Johnson and Johnson responsible for the development of Pharmaceutical Dosage Forms. Development centers are located in the US, Asia and Europe. For the location...
-
(Senior) Scientist Solid Formulation of Novel Oral
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson** Global Chemical and Pharmaceutical Development & Supply (CPDS) is within the Discovery, Product Development & Supply (DPDS) organization of Pharmaceutical Companies of Johnson and Johnson responsible for the development of Pharmaceutical Dosage Forms. Development centers are located in the US, Asia and Europe. For the location...
-
Formulation Scientist
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson**: J&J Innovative Medicine Research & Development develops treatments that improve the health and lifestyles of people worldwide. R&D development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, diabetes, hematology, metabolic disorders, immunologic disorders, pulmonary hypertension and reproductive...
-
Principal Scientist Bio-catalysis
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps pleinCaring for the world, one person at a time, inspires and unites the people of Johnson & Johnson. We embrace innovation—bringing ideas, products, and services to life to advance the health and well-being of people around the world. We believe in collaboration which has led to breakthrough after breakthrough, from medical miracles that have changed lives, to...
-
(Senior) Solid State Scientist in Pharmaceutical
Il y a 5 mois
Antwerpen, Belgique Johnson & Johnson Temps plein**About Johnson & Johnson**: Pharmaceutical & Material Sciences is, within the Pharmaceutical Development & Supply (PPDS) organization of the Pharmaceutical Companies of Johnson and Johnson, responsible for preformulation & biopharmaceutics, solid state form selection, material selection and qualification. In Belgium (Beerse) there is a vacancy for a...
-
Postdoctoral Position in The Lab of Computational
il y a 2 semaines
Antwerpen, Belgique VIB Temps plein**Project description**: The Computational Neurobiology lab studies causal mechanisms underlying normal and aberrant cellular decision-making in the human brain in health and neurodegenerative diseases. We investigate the role of spatial chromatin organization in cell fate acquisition and maintenance, using a variety of targeted and genome-wide profiling...
-
Visiting Tutor Statistics
Il y a 5 mois
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. Departement: Huisartsgeneeskunde en Bevolkingsgezondheid Regime Voltijds **Let’s shape the future - University of Antwerp** The...
-
Senior Researcher or Postdoc in The Lab of
il y a 24 heures
Antwerpen, Belgique Universiteit Antwerpen Temps pleinNiet gevonden wat je zocht? Sla je zoekopdracht dan op en maak een job alert aan op de online sollicitatiemodule om automatisch op de hoogte te blijven van interessante toekomstige vacatures. Meer informatie kan je hier vinden. **Van vrijdag 15 november, 17u tot en met maandag 18 november 2024 is het niet mogelijk om online te solliciteren of je...