Research Fellow
il y a 6 jours
**Introduction**:
The Institute of Tropical Medicine (ITM) is an internationally recognized center for research in tropical diseases. The Department of Clinical Sciences strives for optimal diagnostics and treatment of tropical and globalized infectious diseases with the aim to promote the health of the individual patient. Historically, the department has played an important role in research and education in the field of HIV and tropical diseases. Within the Department of Clinical Sciences, the clinical virology unit (headed by Prof Koen Vercauteren) aims to characterize existing and develop new tools for viral diagnostics. The unit is embedded in ITM’s clinical reference lab that hosts the national reference laboratory for the diagnosis of infectious and tropical diseases, and an AIDS Reference Laboratory. The department also hosts the Belgian National Reference Centre for Arboviruses and for sexually transmitted diseases.
In collaboration with the KU Leuven (KUL) MeBioS-Biosensors group (headed by Prof. Jeroen Lammertyn), we are developing rapid diagnostic tests to detect hemorrhagic fever-causing viruses (such as: Ebola virus and Lassa virus). Commercially available tests for these pathogens, based on antigen detection, lack diagnostic accuracy in real-life situations. Moreover, gold standard nucleic acid amplification technologies (like PCR) are not readily available at the point of care, especially not in low-and-middle-income countries like in Central and Western Africa, where these viruses are endemic or regularly cause outbreaks. Instead, we envision adopting isothermal nucleic acid amplification technologies (like Recombinase Polymerase Amplification; RPA) onto lab-on-a-chip microfluidic devices compatible for easy use at the point-of-care with high diagnostic accuracy.
The clinical virology unit now opens a post-doctoral position for a molecular diagnostician to support the laboratory development and clinical evaluation of RPA assays for viral hemorrhagic fever diagnosis.
Other ongoing research lines in the unit deal with metagenomic sequencing-based viral pathogen detection, T cell receptor sequencing based diagnostics, and mpox (formerly ‘monkeypox’) clinical and molecular virology.
Key words: point-of-care-testing, rapid diagnostic tests, RPA, viral hemorrhagic fever.
**Your role**:
- You will contribute to the laboratory development of RPA assays for viral hemorrhagic fever detection.
- You will contribute to the clinical evaluation of RPA assays for viral hemorrhagic fever diagnosis.
- You will bring short-term research visits to low-and-middle-income countries like in Central and Western Africa.
- You will play a leadership role in driving the research agenda in the group.
- You will write high quality publications for scientific journals and specialist magazines.
- You will represent the research group’s interests in external fora.
- You will contribute to acquiring funding for viral diagnostic research within the group.
- You will build a network of internal and external contacts beyond the boundaries of your specialist field.
- You will contribute to the departmental and the research group’s management, including student supervision.
**Your profile**:
- You hold a master’s degree in (bio)medical or pharmaceutical sciences, biochemistry, biotechnology, or a related field in life sciences.
- You hold a PhD in sciences, on a relevant topic such as molecular biology preferentially in the microbiology (virology) field.
- You have broad expertise in molecular diagnostic test development (such as primer design, and using NCBI blast)
- You have broad expertise in laboratory evaluations of diagnostic molecular tests.
- You take an interest in clinical performance evaluations of diagnostic tests. Previous experience in clinical study management (e.g., study protocol development, biobanking) is a strong asset.
- You hold statistical skills (e.g., for sample size, sensitivity, specificity, positive-, and negative-predictive value, limit-of-detection calculations)
- You have knowledge on regulatory and ethical principles in diagnostic test development.
- Pre-existing knowledge on viral haemorrhagic fever (Ebola, Lassa) clinical virology is an asset.
- You have an interest in developing bioinformatic skills (basic programming skills in R and Python is an asset)
- You have strong conceptual, analytical, and scientific writing skills.
- You are a team player, have good communication skills, experience with student supervision, and a strong capacity for building multi-disciplinary working relationships.
- You have good planning and organizational skills.
- You are highly motivated and have affinity with ITM's objectives and spirit.
- You are flexible and willing to travel occasionally to Central and Western Africa.
- Experience working in low-and-middle-income settings is an asset.
- A track record in obtaining competitive research funding is an asset.
- You speak and write English flu
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