Team Leader Protein Science
Il y a 7 mois
Confo Therapeutics is the only GPCR company with a discovery engine that precisely targets desired GPCR **confo**rmations. This unique capability allows us to unlock a vast untapped potential for the discovery and development of breakthrough medicines. We are advancing a robust pipeline of large and small molecules focused on validated targets in endocrine and metabolic diseases, as well as addressing a broader array of critical unmet medical needs in collaboration with our partners. Our team of around 50 people is dedicated to advancing our technology, expanding our capabilities, and building out our pipeline in order to achieve the best possible therapeutic outcomes for patients
We are seeking a highly motivated and experienced individual to lead our Protein Science team.
You will lead the team using your experience in protein science and structural analysis along with a strong understanding of molecular interactions between protein and small molecules or biologics. This position offers an exciting opportunity to make a significant impact on cutting-edge scientific initiatives.
**Your responsibilities**:
- Design and implement workflows to purify and characterize soluble and membrane proteins expressed in mammalian, bacterial, and insect cells
- Responsible for implementing protein purification and protein quality assessment using several biochemical/analytical techniques
- Enable active and inactive state GPCR complex structures with in house identified compounds via cryo-EM for structure-based drug design
- Working closely with medicinal chemists and CADD to help advance structure based drug discovery, de novo antibody discovery team to generate ConfoBodies and molecular engineering to integrate the critical gene-to-structure activities
- Stay informed with the latest advancements in cryoEM technologies and techniques, particularly in the context of GPCRs, and actively contribute to structural biology efforts
- Maintain excellent relationships with current structural biology contract research organizations
- Supervising and coaching a team of scientists and research associates
- Leading the integrated discovery activities of projects as a core member of project teams: you will be expected to maintain focus and provide direction to the team members with clear project plans and defined timelines
- PhD or equivalent experience in a related field, with at least 5 years of experience in a company (Biotech or pharma)
- Proficiency in protein engineering, cell culture, and protein expression in bacterial, insect, and mammalian systems is required
- Prior experience with GPCR purification and structure determination
- Experience in the entire single particle cryo-EM workflow including protein vitrifications to determine high resolution structures of desired conformational states of integral membrane proteins
- Experience in cryo-EM data collection, data processing to generate electron density maps and model building and working knowledge of associated software tools such as CryoSPARC, ChimeraX, Phenix, Coot, or similar
- Proficiency with Alphafold and/or other computational approaches in the design of proteins, structure prediction using homology modeling, molecular dynamic simulations and protein-ligand docking
- Experience with GPCR biophysical/biochemical characterization (such as fluorescence/analytical-SEC, thermostability, ITC, ligand binding, G protein activation) and screening (thermal shift, SPR, AF-MS, NMR)
- Highly collaborative, self-motivated, team-oriented individual
- Strong leadership experience required
- Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timelines are essential
- You are fluent in English and can communicate research results to the team and cross-functional stakeholders across the company
***:
**Our offer**:
- A competitive compensation package with extensive benefits
- An entrepreneurial and stimulating working environment in a growing and ambitious biotech company
- Opportunities for further professional education and development
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