Scientist in Deep Mutational Scanning

Il y a 3 mois


Gent, Belgique Universiteit Gent Temps plein

**Faculty of Medicine and Health Sciences**:

- **Department: GE31 - Biomoleculaire Geneeskunde**:

- **Occupancy rate:100%**:

- **Number of positions: 1**:

- **Type of employment: Contract of limited duration**:

- **Term of assignment: 6 months**:

- **Wage scale: WM1 to WM4 (master degree)**:

- **Required diploma:Master**

**ABOUT GHENT UNIVERSITY**

Ghent University is a world of its own. More than 15,000 staff members are active daily in education and research, management and administration, technical and social services, and more. It is one of the largest, most exciting, and forward-looking employers in the region and offers great career opportunities. With 11 faculties and over 80 departments, Ghent University offers state-of-the-art study programs grounded in research in a wide range of academic fields.

**DESCRIPTION**

Deep mutational scanning (DMS) is an innovative technique that enables the comprehensive evaluation of all possible genetic variants of a protein simultaneously. By systematically introducing mutations and assessing their impact on protein function, DMS provides detailed insights into the relationships between protein structure and function. This powerful approach has rapidly advanced our understanding of protein interactions, stability, and activity.

At the Center for Medical Biotechnology (VIB-UGent), our laboratory specializes in high-throughput protein mutagenesis studies in mammalian cells to elucidate structure-function relationships, including protein-protein interactions and gene regulation. Over the past decade, we have developed a flexible mammalian DMS platform capable of investigating a wide range of functional properties.

For this project we are seeking a highly motivated scientist with experience in mammalian DMS to further strengthen the capabilities of our team.

**YOUR TASKS**
- You will be involved in the setup, execution, and analysis of a mammalian DMS study
- You will be involved in the further development of the mammalian DMS platform
- You will collaborate with the staff scientist and Ph.D. students working in the team
- You will work in a team located at the VIB-UGent Center for Medical Biotechnology and will interact with other research teams within VIB, UGent, and other Belgian universities.
- At least 70% of your assignment will be spent on academic research.

**WHAT WE ARE LOOKING FOR**
- You hold a master’s degree in Biomedical Sciences or Biochemistry or related areas.
- Experience in deep mutational scanning and deep mutational scanning data-analysis
- Experience in tissue culture and cell line engineering
- Experience in flow cytometry
- Experience with molecular visualization software (YASARA, PyMOL, UCSF Chimera,...)
- You have a sense of planning, organization, initiative, accuracy, detail, and responsibility
- You can work autonomously while having strong team player skills
- You have strong communication skills
- You have excellent written and oral English skills and you are able to vouch for reports about the work

**WHAT WE CAN OFFER YOU**
- We offer you a contract of definite duration for a period of 6 months
- Participation in an exciting and rapidly evolving research field
- Being part of a stimulating and supportive environment with a young, dynamic, and enthusiastic research staff with great team spirit and a broad range of expertise
- Access to state-of-the-art technology and facilities
- Institutional training opportunities to broaden your expertise and skills
- All Ghent University staff members enjoy a number of benefits, such as a wide range of training and education opportunities, 36 days of holiday leave (on an annual basis for a full-time job) supplemented by annual fixed bridge days, a bicycle allowance, and eco vouchers,... Comprehensive overview of our employee benefits
- Your remuneration will be determined by salary scale WM1 to WM4. Click here for more information about our salary scales.

**INTERESTED?**
- In the field ‘CV’: your CV in pdf format
- In the field ‘Diploma’: a transcript of the required degree (if already in your possession). If you have a foreign diploma in a language other than our national languages (Dutch, French, or German) or English, please add a translation in one of the mentioned languages.
- In the field “other documents”: a reference letter,

Note that the maximum file size for each field is 10 MB.

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