Senior Scientist Interventional Oncology
il y a 5 jours
At J&J, we are working to build a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease. We bring together the best minds and pursue the most promising science, and we collaborate with the world for the health of everyone in it. Interventional Oncology, is a cross-sector initiative, charged by the Executive Committee of J&J to alter the course of lung cancer and improving survival by intercepting and curing lung cancer.
ESSENTIAL FUNCTIONS: (CORE Responsibilities)
1. Design and execute immune based assay development to support pre-clinical drug development projects, in particular utilizing cancer cell, fibroblast, myeloid and T-cell based co-cultures.
2. Design and conduct novel research to support target validation of current and future targets in the INTO. Support biology of project teams as core member.
3. Supervision of lab-based associate scientist level colleagues to support their pre-clinical validation experiments and career development.
4. Support pre-clinical in vivo work including design and execution of in vivo experiments, monitoring progress, analysis of results and presentation to INTO leadership teams. In addition, in vivo model development is an important part of the role.
5. Support pre-clinical and clinical project team and solution development teams in presentation and explanation of impact of pre-clinical data packages.
6. Support collaborations with academic investigators including advising on experimentation, analysis of results and conducting complementary experimentation.
**Qualifications**:
- A minimum of a PhD degree in Life Sciences (Pharmacology, Immunology or Oncology) with a minimum of 5 to 7 years of relevant laboratory-based experience (tumor-inflammation) in industry/biotech or an academic setting is required.
- Scientific track-record in field of immune-oncology.
- Experience in training/mentoring lab-based associate level scientists.
- Proven advanced experience in flowcytometry (panel design, multi-parameter analysis,).
- Highly experienced with hands-on animal handling in oncology-relevant rodent models such as subcutaneous and orthotopic tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
- Experience with the adherence to animal welfare and compliance regulations is required.
- Drug administration by subcutaneous, intraperitoneal, intravenous tail vein injections and oral gavage. Blood collection by tail vein, saphenous vein and cardiac puncture. Perform animal autopsy/dissection and microsurgery, perfusion and tissue collection.
- Experienced with cell culture of cancer or immune cells required, experience in endothelial cell biology is a plus.
- Experience in tumor metabolism is a plus.
- Experienced with bioluminescent imaging, flow cytometry, IHC, ELISA is required.
- This position may require occasional weekend, evening, and holiday dosing/animal monitoring.
Other Requirements
- Must have excellent interpersonal skills, with the ability to interact effectively with people.
- Must have strong organizational, data management, and record-keeping skills.
- Must have excellent verbal and written communication skills in English
- Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
- Knowledge of Microsoft Office and Graphpad Prism.
- Learning agility and ability to work across projects highly desirable
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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