Principal Scientist Pharmacology

Confo Therapeutics is the only GPCR company with a discovery engine that precisely targets desired GPCR **confo**rmations. This unique capability allows us to unlock a vast untapped potential for the discovery and development of breakthrough medicines. We are advancing a robust pipeline of large and small molecules focused on validated targets in endocrine and metabolic diseases, as well as addressing a broader array of critical unmet medical needs in collaboration with our partners. Our team of around 50 people is dedicated to advancing our technology, expanding our capabilities, and building out our pipeline in order to achieve the best possible therapeutic outcomes for patients

We are seeking a **Principal Scientist Pharmacology**, who will be a key member of the research team, and will be providing strong scientific, operational and strategic input.

**Your responsibilities**:
His/her duties shall include, but not be limited to:

- Define the translational strategy on projects, with the objective to inform preclinical and clinical development: indication(s) identification, target coverage, PK/PD, biomarker strategy,
- Designing, assessing and reporting in vivo pharmacology in small animal models
- Coordinating activities with CROs and ensure optimal protocol design and execution,
- Lead, develop and organize in vivo biology activities in all projects; maintain focus and provide direction to the project leader and team members;
- Ensure smooth communication and interactions with the other teams and all stakeholders, including relevant functional areas in the Development organization
- Contribute to external budgeting exercises
- Participate in relevant operational, scientific and/or project meetings and presentation of scientific output
- Present complex scientific data in a clear, comprehensive manner
- Writing high quality internal reports for inclusion e.g. in peer reviewed publications or regulatory submissions
- Establish and maintain a network in the external environment; engage with academic KOLs
- Solid knowledge of drug discovery and development processes, Ph.D. (or equivalent) with at least 6 years of industrial experience, with relevant work experience in drug discovery and development through in vivo pharmacology, translational medicine or related discipline
- Knowledge in the endocrine/metabolic therapeutic area is a plus
- Good understanding of target biology, on how molecular targets/pathways can be modulated in vitro and in vivo
- Expertise in designing in vivo pharmacology studies to inform human translation and relevance, and support a variety of research efforts including pharmacokinetics, pharmacodynamics, mode of action, target validation and lead identification.
- Critical mind-set when looking at scientific data, both from internal and external sources
- Ability to support multiple projects within a matrix-based organization and via external collaborations
- Experience in project leadership in industry settings; function as project leader for cross-functional teams to achieve project goals and communicate regularly with project team and other stakeholders
- Creative and able to bring new ideas from scientific literature and integrate knowledge coming from different sources; pragmatic and problem solver attitude
- Exceptional attention to detail
- Excellent organization and communication skills
- Open-minded, ability to adopt knowledge and learnings on different drug modalities (agonist antibody and small molecule) and translate to meaningful in vitro and in vivo biology read-outs

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**Our offer**:

- A competitive compensation package with extensive benefits
- An entrepreneurial and stimulating working environment in a growing and ambitious biotech company
- Opportunities for further professional education and development