(Senior) Research Associate in Vivo Pharmacology
Il y a 7 mois
eTheRNA immunotherapies was founded in 2013. eTheRNA has established an integrated set of proprietary capabilities for an end-to-end solution to design, develop and manufacture next-generation mRNA products based on enabling technologies. eTheRNA’s business model will utilize this suite of capabilities to provide superior products for partners in both early-stage research as well as later-stage development for mRNA therapeutics. eTheRNA will leverage its proprietary molecular designs, lipid biochemistry expertise, customized lipid nanoparticle formulations (cLNPs), mRNA-based T cell adjuvants, and advanced manufacturing processes to overcome the current challenges facing the development of mRNA therapeutics. By expanding its significant expertise in designing, synthesizing, and manufacturing cLNPs with a spectrum of properties suitable for a range of prophylactic and therapeutic indications, this innovative business model will allow the company to accelerate near-term revenue growth through technology licensing and mRNA cGMP manufacturing services for multiple future partners.**
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**General job description**:
- You will contribute to the development of innovative RNA-based formulations with a particular focus on in vivo pharmacology. This is a highly-collaborative, hands-on position at the interface of discovery, CMC and preclinical activities. As a key member of integrated multi-disciplinary teams, you will work in a matrix environment where initiative, close teamwork and technical scientific expertise is required. The position requires organization, excellent communication and technical skills and a capacity for constant innovation in the pursuit of company goals. The Research Associate is a hands-on person responsible for in vivo animal models and ex-vivo tests including input on the implementation, optimization and validation of new methods. This position reports to the Senior Scientist in vivo Pharmacology and will be based in our research site in Zwijnaarde (Ghent), Belgium.The duties shall include, but are not limited to:
- Perform _in vivo _experiments to assess the efficacy, safety and mode-of-action of etherna’s mRNA immunotherapies.
- Independently plan and execute _in vivo _and _ex-vivo _experiments, upon approval.
- Mice manipulations including injections (intramuscular, intravenous, intraperitoneal, subcutaneous), blood collection, weight measurements, muscle swelling, and _in vivo _imaging, organ dissection and _ex-vivo _imaging.
- Generation and characterization of formulations for mRNA delivery.
- Analysis of harvested cells and biological materials using techniques such as flow cytometry, ELISA, ELISPOT.
- Cell culture of murine cell lines and primary cells required for _ex-vivo _assays (including splenocytes, PMBCs, bone marrow cells).
- Assist in the development of new assays, including optimizations and writing/adjustment of protocols and SOPs.
- Compile and analyze data to assist and present in project team or other internal meetings and maintain a detailed electronic lab book related to ongoing experiments.
- Assist in keeping track of relevant advancements in the field by means of literature search.
- Assist in maintaining a clean and tidy lab environment and share common maintenance tasks, including the animal facility.
**Job Requirements**:
- Education-
- Professional bachelor’s degree in biomedical laboratory Techniques or master’s degree in biomedical sciences/Biotechnology or related field or equivalent relevant laboratory experience
- FELASA B/C certified.Experience- Prior experience in in vivo studies and animal handling is mandatory.
- Preferably 3-5 years of relevant experience in a research environment focused on biotechnology, biology, immunology or related field, either in academia or biotech.
- Experience with the culture of cell lines for in vivo models and with immunological assays is a plus.
- Experience with flow cytometry is an advantage.
- Basic knowledge of statistics is preferable.
- Animal colony management experience (and knowledge of colony management software) is an advantage.Other qualifications and skills- Detail-oriented and accurate in following instructions, record keeping and completion of reports.
- Able to perform experimental troubleshooting and to propose technical solutions.
- Scientific integrity.
- Good communication skills.
- Well organized, well-structured, hands-on, result focused.
- Able to work under stringent timelines.
- Ability to foster teamwork and a collaborative atmosphere. Ability to work effectively both independently and as part of a team with multiple cultural backgrounds.
- Enthusiastic, flexible and able to multitask. Flexibility dealing with changing priorities and the capacity to continuously prioritize is required.
- Proficient in written and spoken English.
- Knowledge of MS Office (Excel, Word, PowerPoint, Outlook) and Prism.**Our Offer**:
- An exciting job in a dynamic and entrepreneurial environment with ro
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