Research Associate Mrna Formulation

il y a 2 jours


Zwijnaarde, Belgique eTheRNA Temps plein

eTheRNA immunotherapies was founded in 2013. eTheRNA has established an integrated set of proprietary capabilities for an end-to-end solution to design, develop and manufacture next-generation mRNA products based on enabling technologies. eTheRNA’s business model will utilize this suite of capabilities to provide superior products for partners in both early-stage research as well as later-stage development for mRNA therapeutics. eTheRNA will leverage its proprietary molecular designs, lipid biochemistry expertise, customized lipid nanoparticle formulations (cLNPs), mRNA-based T cell adjuvants, and advanced manufacturing processes to overcome the current challenges facing the development of mRNA therapeutics. By expanding its significant expertise in designing, synthesizing, and manufacturing cLNPs with a spectrum of properties suitable for a range of prophylactic and therapeutic indications, this innovative business model will allow the company to accelerate near-term revenue growth through technology licensing and mRNA cGMP manufacturing services for multiple future partners.

***

**General job description**:

- The Research Associate mRNA formulation is a hands-on person responsible for the formulation of mRNA into lipid-based nanoparticles and polymeric nanoparticles, the physicochemical characterization of these mRNA formulation and their in vitro assessment using cellular assays. This position provides also input on the implementation, optimization and validation of new methods.This position reports into the Scientist mRNA Formulation and will be based in Ghent.

**Responsibilities and Duties**:
The Research Associate mRNA Formulation’s duties shall include, but not be limited to:
- Synthesis of lipid-based nanoparticles
- Performing physico-chemical characterization including determination of pKa, zeta-potential, mRNA encapsulation and size determination
- Performing
- _in vitro_ transfection experiments
- Performing and evaluating
- _in vitro_ cellular assays**Job requirements**:
**Education**:
Professional Bachelor in Biomedical Laboratory Techniques or Master in Biomedical Sciences/Biotechnology/Pharmaceutical Sciences or related field or equivalent relevant laboratory experience

**Experience**:
- Minimum of two years of relevant laboratory experience (can be both academic or industrial)
- Experience in cell culture and immunological assays
- Experience in flow cytometry
- Broad knowledge of molecular biotechnology techniques (cloning, DNA/RNA isolation, RT-QPCR, Western Blot)
- Prior experience in animal handling (FELASA B certificate) is considered a plus
- Prior experience in formulation of polymer and/or lipid-based nanoparticle delivery systems is considered a plus
- **Other Qualifications, Skills and Abilities**:
- Detail-oriented and accurate in following instructions, record keeping and completion of reports
- Able to perform experimental troubleshooting and to propose technical solutions
- Scientific integrity
- Proficient in written and spoken English
- Good communication skills
- Well organized, well-structured, hands-on, result focused
- Able to work under stringent timelines
- Ability to foster teamwork and a collaborative atmosphere
- Enthusiastic, flexible and able to multitask
- Understanding of MS Office (Excel, Word, PowerPoint, Outlook)**Our offer**:
- An exciting job in a dynamic and entrepreneurial environment with room for personal development
- Employment contract of unlimited duration with a competitive salary package with a lot of extra benefits
- Work within a dynamic and innovative group with great colleagues



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