(Senior) Scientist in Vivo Pharmacology/toxicology
il y a 4 jours
eTheRNA immunotherapies was founded in 2013. eTheRNA has established an integrated set of proprietary capabilities for an end-to-end solution to design, develop and manufacture next-generation mRNA products based on enabling technologies. eTheRNA’s business model will utilize this suite of capabilities to provide superior products for partners in both early-stage research as well as later-stage development for mRNA therapeutics. eTheRNA will leverage its proprietary molecular designs, lipid biochemistry expertise, customized lipid nanoparticle formulations (cLNPs), mRNA-based T cell adjuvants, and advanced manufacturing processes to overcome the current challenges facing the development of mRNA therapeutics. By expanding its significant expertise in designing, synthesizing, and manufacturing cLNPs with a spectrum of properties suitable for a range of prophylactic and therapeutic indications, this innovative business model will allow the company to accelerate near-term revenue growth through technology licensing and mRNA cGMP manufacturing services for multiple future partners.
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**General job description**:
This position reports to the Principal Scientist Pharmacology and will be based in our research site in Ghent, Belgium.
**Responsibilities and Duties**:
- Designing, assessing and reporting of pharmacodynamics, biodistribution, immunogenicity and safety/toxicity in preclinical studies
- Designing, assessing and reporting in vivo pharmacology in small animal models and/or human samples
- Prioritize workflow and follow challenging timelines of multiple projects to achieve project and company goals according to budget
- Coordinating activities with CROs
- Lead, support and manage the experimental work of research assistant(s)
- Writing reports and preparation of regulatory documents
- Contribute to the development of RNA delivery technology and the generation of intellectual property
- Present data internally, at scientific conferences and at meetings with partner organizations and/or regulators**Job requirements**:
**Education**:
- PhD in life science
- FELASA B certification
- **Experience**:
- 3+ years of experience in working in biotech or pharmaceutical industry, preferably in toxicology
- Planning, executing, analyzing and reporting of preclinical efficacy and safety/toxicity studies
- Knowledge about relevant ICH guidelines
- Experience in experimental in vivo models for monitoring biodistribution, cellular targeting, immune activation and treatment efficacy
- Advanced scientific writing skills
- Project management expertise and training would be an advantage
- Supervision of research technicians
- Worked in a matrix environment
- Experience of nucleic acid research would be an advantage but not essential
- **Other Qualifications, Skills and Abilities**:
- Energetic and ambitious
- A strong team player
- Goal
- and timeline-oriented work
- High quality awareness
- Well developed communication skills
- Proactive and flexible mindset who fosters innovation
- Hands-on mentality
- Capability to work in a highly dynamic environment
- Proficiency in English**Our offer**:
- An exciting job in a dynamic and entrepreneurial environment with room for personal development
- Employment contract of unlimited duration with a competitive salary package with a lot of extra benefits
- Work within a dynamic and innovative group with great colleagues
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