Vp, Global Head Chemical Process R&d
il y a 5 jours
As the world's largest and most broadly based healthcare company, we impact more than a billion lives through the innovation happening at 260+ companies located in 60 countries around the world. Teams from Johnson & Johnson’s Medtechs are 3-D printing artificial joints personalized for each patient, while researchers in pharmaceuticals are using AI to discover lifesaving drugs. We redefine what it means to be a big company in today’s world.
**For our pharmaceutical sector, we are currently recruiting a VP, Global Head Chemical Process R&D (M/F) on a permanent contract. The role is based in our Beerse campus (Belgium).**
**Objectives and responsibilities**
The role has overall responsibility for the Chemical Process Research and Development (CPRD) organization within J&J Innovative Medicine Therapeutics Development & Supply. This team of >200 scientists and engineers covers all aspects of chemical process development to deliver optimal manufacturing processes, and supply of clinical synthetic active pharmaceutical ingredient (API); including small-molecules, peptides, oligonucleotides and antibody-drug conjugates. The group also provides chemistry R&D support for Discovery Sciences, develops content for regulatory submissions and carries out due diligence for L&A deals. The jobholder also manages all aspects of late-stage development, the technical transfer of products to our commercial supply network and subsequent lifecycle management support.
The jobholder sets the overall direction for the organization, covering continuous scientific and technology advancement while benchmarking and evolving the strategy in response to regulatory and broader industry trends. The role also has accountability for sourcing strategy, site-missions and geographic footprint, ensuring an appropriate balance of MAKE versus BUY to provide adaptability to changes in portfolio demand. Additionally, the job holder will have responsibility for staffing and budgeting for the organization. The engineering activities within the scope of this role include all CPRD capital engineering and budget ownership, process engineering, and manufacturing, science & technology engineering.
As part of the Synthetics Development leadership team (covering drug substance, drug product and analytical development) the incumbent plays a substantive role in defining and shaping the long-term business strategy as well as the end-to-end delivery of the portfolio.
The jobholder will have a proven ability to lead, manage and develop a diverse and inclusive team and to build a group that enables industry-leading development of small molecules. The jobholder will have technical and scientific expertise and significant experience acquired through developing and filing synthetic therapeutics.
**Specific Missions**
- Ensure that CPRD delivers maximum value through the development and commercialization of safe, high quality, robust, sustainable and cost-effective synthetic API processes.
- Direct involvement on portfolio projects via (1) Governance and decision-making: member of CMC Council, cross-functional reviews, peer review within the function; (2) ongoing oversight of all development and clinical trial material activities within CPRD; (3) external representation towards health authorities, collaborations and the general scientific community, and (4) direct participation in technical issue resolution.
- Responsible for developing and implementing the overall global strategy for synthetic drug-substance development to assist development of molecules spanning discovery, early
- and late-phase development as well as commercial lifecycle management. This involves the leadership of R&D teams in China, Belgium, US & Switzerland as well as external CRO’s in delivering best in class science to meet the requirements of the business.
- Responsibility for the integrity of science associated with process R&D as well as commercial product support with respect to investigations arising in JJIM Supply Chain.
- Lead a ’best in class’ R&D organization, continually improving scientific capabilities for drug-substance development by embracing emerging technologies, fostering innovation and intensively developing talent across teams. This will also include formation of a consistent knowledge management framework, capturing, sharing and institutionalizing all key information and learnings across the organization.
**Operational management**
- Owns primary budgetary accountability for CPRD and aligns strategy across both TDS and the Therapeutic Areas
- Responsible for creating a culture of scientific excellence which drives value through highly effective teams to increase efficiency, reduce cost, accelerate programs and ensure quality
- Act as a role model for embedding a culture of compliance with safety procedures, healthcare compliance, training, and local regional and global regulations, in line with the J&J Credo.
**People Development**
- Responsible for leadin
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